Day 1 :
Time : 10:00-10:40
Dilip Ghosh has received his PhD from India. He is an international speaker, facilitator and author and professionally associated with Nutriconnect, Australia; Honorary Ambassador, Global Harmonization Initiatives (GHI). He is a fellow of American College of Nutrition (ACN), professional member of Australian Institute of Food Science & Technology (AIFST), an advisor and executive board member of Health Foods and Dietary Supplements Association (HADSA), India and also in editorial board of several journals.
Dilip Ghosh has published more than 90 papers in peer reviewed journals, numerous articles in food and nutrition magazines and books. His most recent book, “Pharmaceuticals to Nutraceuticals: A shift in disease prevention” under CRC Press, USA has been published in 2016.
It is generally accepted worldwide that modern pharmaceuticals will remain out of reach of many people and “health for all” may only be materialized by the use of adequately assessed nutraceutical or phytomedicinal products. The human has been using food bioactive and/or herbal medicine for healing purpose from the beginning of human civilization. In recent times, use of herbal medicine for healthcare has increased steadily all over the world although it was neglected for decades by Western societies. However, the gaps in relation to the safety, claimed efficacy, and quality of herbal products used as herbal medicine, nutraceuticals, health foods, and cosmetics are being realized and addressed by many companies in their product development framework. The combination therapy of the pharmaceuticals and food bioactives in disease prevention and treatments is one of the most discussed topics in recent time.
The transition of the pharmaceutical industry from its traditional business model is ongoing and interesting to see how their next blockbuster molecule could be derived through different routes. It is proposed that the industry is challenged with three interrelated tipping points referring to what the industry sells (service models vs. therapies), to whom (mass markets vs. niche), and how it should organize itself (making connections vs. integration). The transition from current ‘high-risk, high-margin’ business model to ‘low cost high volume’ nutra business model is dependent on many factors and also advised to move into less regulated markets like animal and consumer health.
This presentation will cover:
- Paradigm Shift in Healthcare Industry: From Pharma to nutra
- Change of consumer focus: From illness to wellness
- Peripheral opportunities are also exist for managing chronic lifestyle diseases and ailments
- Combination therapy of pharmaceuticals and food bioactive in disease prevention and treatments
- “Health for all” target is only possible by the use of adequately assessed nutraceutical/phytomedicinal products.
German University in Cairo, Egypt
Time : 10:40-11:20
Ashraf Abadi has completed his PhD from the College of Pharmacy, University of Florida, USA and Cairo University. He is the head of Pharmaceutical Chemsitry Department, Faculty of Pharmacy and Biotechnology, German University in Cairo and former Dean of the Faculty. He has published more than 80 papers in reputed journals and 7 patents and has been serving as an editorial board member and reviewer of reputed international pharmaceutical sciences journals. He supervised more than 6- Master and Ph.D. theses in the field of Drug Discovery and Pharmaceutical Chemistry.
NS5A is a dimeric protein and an interesting target to inhibit the replication of HCV. Reported here are two series of symmetric molecules with the scaffolds of 4, 4'-(buta-1,3-diyne- 1,4-diyl) dianiline core- and 3, 3'-(buta-1,3-diyne- 1,4-diyl) dianiline core, connected to a L/D-proline moiety, and capped with the methyl, ethyl, butyl, isobutyl and benzyl carbamate of L/D-valine, L/D-leucine and L-isoleucine amino acids. The compounds showed inhibitory effect on the replication of HCV genotype 1b in vitro with EC50s in the low picomolar range and SI50s of several orders of magnitude, Also some of the compounds showed pan-genotypic activitiy. Higher activities were associated with compounds showing curving of the core scaffolds that leads to better fit and interaction with the desired target.
ITS College of Pharmacy, India
Time : 11:40-12:20
Presently, S Sadish Kumar is the Director of I.T.S College of Phamacy, Ghaziabad, India. He has been working as a Professor since 2010. He has over 2 decades of Research and Teaching experience.
He is a member of various professional bodies including Royal Society of Chemistry (RSC), UK. He has published 2 books, 30 research articles & presented research papers at conferences held in South Korea, USA, Germany & Egypt and guided over 30 MPharm research projects in Marine and other natural products, guiding PhD projects as well.
His biography has been cited in Marquis Who’s Who in Medicine & Healthcare. He has been selected and commemorated for International Einstein Award for Scientific achievement, International Health Professional of the year to mention a few. His research thirst on Marine algae is widely noted.
For the past few decades, compounds from Marine algae have been gaining importance due to the vast chemical diversity. In our continuous research on algae, scientific data and traditional claims prompted us to investigate on the brown alga Turbinaria ornata (Family: Sargassaceae). The Cyclohexane, Ethyl acetate and Methanolic extracts of Turbinaria ornata were subjected to wide pharmacological screening. Among the extracts, Cyclohexane exhibited cholinomimetic activity by inhibiting the Cholinesterase significantly at P<0.01 in the presence of acetyl choline, Ethyl acetate extract possessed antifungal activity with the MIC of 500 mcg/mL concentration and Methanolic extract showed the highest in vitro DPPH free radical scavenging activity (70.78%) which was comparable to Ascorbic acid, a positive control (78.16%). Also it showed significant anti diabetic activity against Streptozotocin and anti obesity activity against Atorvastatin (P<0.001).
- Pharmaceutical Analysis | Nanomedicine and Nanotechnology | Drug Safety and Pharmacovigilance | Industrial and Physical Pharmacy
Location: Novotel Melbourne On Collins
MONASH University, Malaysia
Ezharul H Chowdhury is currently holding an Associate Professor position and a cluster leader of 'Biomedical Engineering' under Advanced Engineering Platform (AEP) at MONASH University (Sunway Campus). Prior to this appointment, he was a Senior Lecturer at International Medical University (IMU) since September 2008 and an independent Assistant Professor of Tokyo Institute of Technology (Tokyo Tech) as well as a Visiting Professor at Shizuoka Cancer Center Institute since 2006. He was awarded with 'Doctor of Engineering' in 2003 by Tokyo Tech where he also carried out a post-doctoral study and subsequently, served as a team leader. He has pioneered the development of a range of pH-sensitive inorganic nanoparticles as smart tools for efficient and targeted intracellular delivery of genetic materials, gene-silencing elements, proteins and classical anti-cancer drugs. He is currently applying this smart nanotechnology for the treatment of cancer, particularly breast carcinoma and cardiovascular diseases, such as diabetes. His team is now conducting pre-clinical trials with some interesting nano-formulations of classical anti-cancer drugs, therapeutic gene(s) and anti-sense RNAs (siRNAs). His research team is thus one of the leading groups in the world, having original and unique contributions in this multidisciplinary field. Currently he is supervising 8 PhD students and 1 Master student. His research projects have so far been funded internally through institutional grants as well as externally by the Japanese Government's Ministry of Education, Culture, Sports, Science & Technology (MEXT), Japan Society for the Promotion of Science (JSPS), the Malaysian Ministry of Science, Technology and Innovation (MOSTI) and Ministry of Higher Education (MOHE). He works as editorial board members for 5 international journals. His outstanding contributions have so far produced over 70 publications in the international journals of high repute and 5 Japanese and US patents.
Regardless of the administration routes, delivery of small molecule drugs to their target sites of action historically poses one of the biggest challenges due to their homogeneous tissue distribution, renal clearance and lack of target specificity. Nanotherapeutics have evolved as novel drug formulations at dimensions of roughly 1–100 nanometers by virtue of the integration of nanotechnology with medicine for treating and preventing critical human diseases effectively and precisely. The favorable pharmacokinetics with prolonged circulation time, selective endothelial permeability at several target tissues and high specificity for biological targets are the attractive attributes of nanopharmaceuticals driving the pharmaceutical industries to conduct a large number of pre- clinical and clinical trials, with enormous successes seen in the past in getting approval and commercialization of nanotechnology-based medical products. Diversified approaches based on synthetic, recombinant, hybridoma and phage display technologies have been undertaken to fabricate a variety of nanoparticulate and macromolecular carriers and drugs in order to overcome the multi-step extracellular and intracellular barriers and to facilitate development of novel strategies for therapeutic delivery and imaging.
RVS College of Pharmaceutical Sciences, India
C.S. Kandasamy has completed his PhD at the age of 42 years from SunRise University and postgraduate studies from the TamilNadu Dr. M.G.R. Medical University, Chennai. He is the Professor & Vice Principal of RVS College of Pharmaceutical Sciences, a premier Pharmaceutical educational service organization. He has published more than 25 papers in reputed journals and has been serving as an editorial board member of repute.
Background: Diseases are destroyers of health, well being, and life. So, Arogya is the main constituent for excelling in life. Jaundice is one disease which has manifested itself as a curse for many years. Even today, there is no good allopathic medicine for treatment and complete cure of jaundice. This study aims to make a formulation for the cure of jaundice by combining various herbals to cure jaundice.
Methods: Based on the ethnomedical literature reviews, the crude drugs such as cardamom, ajowan, cinnamon, coriander, cumin, clove, ginger, and nutmeg were collected and subjected to various pharmacognostical, phytochemical, and analytical studies to assess its quality. After confirming the quality, the hepatoprotective polyherbal formulation (HEP-PRO) was formulated and their efficacy was analysed using various analytical and pharmacological studies. To assess the safety of HEP-PRO, clinical trials were conducted using this formulation at Ayushkaram Ayurveda Hospital, Coimbatore after obtaining Human Ethical Clearance approval by IEC, Institute of Applied Dermatology, Kasaragod.
Results: The present study has been carried out in 30 patients. All the patients were given HEP-PRO at a dose of 60 ml three times a day one hour after food. HEP-PRO provided significant relief in pyrexia by 36% (P<0.015), fatigue and yellow discoloration of sclera by 27 & 39% respectively (P<0.025), and yellow discoloration of urine by 32% (P<0.010). This also has reduced the yellow discoloration of nail and yellow discoloration of skin by 60% with a P value of 0.001, which is also statistically significant.
Conclusion: HEP-PRO has proved its efficacy in the management of jaundice.
Sri Vidyanikethan Engineering College, India
Prakash Kinthada is a Professor in Chemistry at Sri Vidyanikethan Engineering college, JNTU University in Ananthapur, A. Rangam Peta, Tirupathi, India.
Cancer is a dreadful disease and any practical solution in combating this disease is of paramount importance to public health. Cancer patients have burdened by drug induced toxic side effects, and no turned to seek help from the complementary and alternative medicine hoping for a better cure. Research on Platinum based drugs and Non Platinum based drugs is a Multi-Million Dollar Industry in USA and there is every need to produce safe drugs for the cure of this monstrous disease. Flavonoids have a long history of use in traditional medicines in many cultures. The phytochemical, curcumin is one of the major dietary flavonoid, belonging to a group of flavonol, Curcumin is a natural polyphenol. It is highly potential molecule capable of preventing and treating various cancers. Various dietary chemo preventive agents, turmeric powder or its extract are broadly used as therapeutic preparations in Indian System of medicine. We provide a summarized synthesis and structural determination of Curcumin Oxime, Curcumin Thiosemicarbazone derivative of Gold (III) complex. The use of these analogs for prevention of cancer tumor progression and treatments of human malignancies. A pharmacologic agent for treating and/or preventing cancer, among other diseases and conditions, and particularly breast, prostate, and pancreatic cancer, in humans and animals. The novel pharmacologic agent is an isoflavonoid or isoflavonoid mimetic covalently attached to a cytotoxic pharmacophore that, preferably has the ability to conjugate with a metal salt to form a more potent metal complex, particularly a Au (III) complex and other complexes of Platinum, Palladium, Ruthenium, Copper etc.
My talk would mainly encompass different Transition Metal Complexes/Organometallic Compounds that are presently used as drugs, especially Anticancer and Anti-HIV drugs, apart from Anti-inflammatory, Antimicrobial, Antibacterial and diseases like Arthritis and Parkinson’s Disease etc. The talk would mainly focus on the use of Medicinal Chemistry and it’s application to Drug Design and Development in Pharmaceutical Industry , especially Transition Metal Complexes and Organometallic Compounds viz. Gold, Platinum, Palladium And Ruthenium apart from Copper, Cobalt, Iron, Nickel, Zinc, Cadmium etc.
The main emphasis of my talk would be on Different class of Ligands, their Schiff’s Bases and Transition Metal Complexes especially Au, Pt, Pd and Ru, with the main aim of designing, developing very novel small molecules, as possible and extremely potential candidates as Anti-cancer and Anti-HIV drugs. The talk would provide an overview of current programs being undertaken in our laboratories, especially focused on the development of potent ligands capable of recognizing Binding sites and diverse strategies employed by my group for elucidation of Anti-Cancer and Anti-HIV drug Leads to Circumvent the problem caused by Cis-Platin.
We have synthesized and characterized several phytochemicals from Traditional Medicinal Plants and isolated some phytochemicals and made the corresponding Oximes, Thiosemicarbazones and Substituted thiosemicarbazones as ligands and synthesized, characterized, structurally elucidated their Transition Metal Complexes especially with Gold, Platinum, Palladium, Ruthenium, Copper etc. and Studied their Anticancer Activity, Nuclease activity etc. and tested their potential as Anticancer Drugs.
The main aim of our extensive/preclinical Pharmaceutical development program is to investigate the use of these extremely novel small molecules-metal complexes/compounds of phytochemicals, flavanoids etc., which have very interesting structural features and properties and hence are excellent candidates as Anti-Cancer and Anti-HIV drugs .The main aim of our research is Design ,Development and Synthesis of Transition Metal Complexes/ Organometallic Compounds that would certainly help to bring this force of nature from BENCH to BEDSIDE and enhance Cancer Killing with less toxic effects and would certainly lead to initiation of clinical trials.
Taif University, KSA
Ahmed M A Masaad is concerned with discovery of new drugs and he have innovations in many new drugs and drug delivery systems. He have memberships of many scientific society and editor of PSC journal. He published more than twenty scientific researches in many sides of pharmacy, he have discovered new treatment of cancer of colon and skin. He possess innovative certificates in drugs delivery system and new drugs which published in scientific journal.
Hemorrhoids, also called piles, are vascular structures in the anal canal. In their normal state, they are cushions that help with stool control. They become a disease when swollen or inflamed; the unqualifiedly term "hemorrhoid" is often used to refer to the disease. The signs and symptoms of hemorrhoids depend on the type present. Internal hemorrhoids are usually present with painless, bright red rectal bleeding when defecating. External hemorrhoids often result in pain and swelling in the area of the anus. If bleeding occurs it is usually darker. The new treatment is mainly depend on mechanism of contract the connective tissue surrounding the venous around anus by effervescent tannin base with strong anti-bacterial, antifungal and anti-viral effect of formula. The safety of drugs was tested in rabbits, rats first and then the experiment was done in hundreds of patient under license of ethics committee of Taif University. The percentage of cure conducted was 99%, this success leads to relive of pain over millions of patients around the world and minimize the risk of surgery treatment and cost beside quick relive of disease in two to three weeks with no chance of relapse of disease again.
Anteneh Assefa Kebede has completed his MSc in Pharmaceutics from Addis Ababa University, the premium university in the country, and B.Pharm from University of Gondar, College of Medical Sciences. He is now serving as a lecturer in the department of Pharmacy, college of Medical and Health Sciences, Wachemo University, which is a government University. Currently he is serving as the dean of the school of Pharmacy. The two names mentioned above are my supervising professors during the research work.
Starch is the most commonly used pharmaceutical disintegrant in tablet formulations. The aim of the present study was to assess the disintegrant property of Ethiopian potato (Plectranthus edulis) starch in comparison to Irish potato starch and its optimization in paracetamol tablets formulations - prepared by wet granulation method. Tablet properties such as crushing strength, friability, disintegration time, and dissolution rate of the tablets were studied for both comparison and optimization studies. The results of comparative study showed that the properties of paracetamol tablets formulated with both starches as disintegrants were affected by their concentration and the compression force (CF); and P. edulis starch exhibited a favorably comparable disintegrant property with Irish potato starch in paracetamol tablet formulations. The study also showed that the CF and disintegrant concentration had significantly affected the response variables (i.e., the crushing strength, friability and disintegration time); hence, these factors were further optimized using central composite statistical design. The optimal conditions were obtained at a CF of 14.40 KN and disintegrant concentration of 5.96%. Under these conditions, the crushing strength, friability and disintegration time were 101.8 KN, 0.3% and 1.34 min, respectively. These values closely matched with the predicted values of the responses at the aforementioned levels of the factors. Thus, the results of this study indicated that Ethiopian potato (P. edulis) can be used as an alternative source of starch for its application as a disintegrant in the tablet formulations.
Dawit Simegnew has completed his BPharm at the age of 24 years from University of Gondar. Currently, he is working as Clinical pharmacist at Shambu General Hospital. He has 4 published original research articles in peer-reviewed journals. He was also awarded by Ethiopian pharmaceutical association in 2014/15 for his outstanding academic achievements in pharmacy.
The sale of antibiotics without medical prescription has been observed in many countries. The practice is more pronounced in developing and low income countries where legislations and regulations are weak. In these countries, antibiotics are illegally purchased without medical prescriptions and very little effort has been made to tackle the situation. The role of pharmacists in contributing to healthcare remains debatable. In Ethiopia, there are deficiencies in the quality of current professional practice. Community pharmacists are now seen as retailers and businessmen rather than health care providers. Ethiopians are therefore left to accept the helpful and harmful practices such pharmacists. Self-medication with antibiotics is a universal problem and variations regarding such practices are obvious around the globe. The practice cuts across culture, gender, age, health status, social status, race and occupation. Irrational use of antibiotics increases the risk of bacterial resistance and adverse drug reactions. It has been found to produce various adverse effects in humans. It is the objective of this paper to discuss the irrational use and non-prescription sale of antibiotics in Ethiopia. It will discuss the evidence, the concept of self-medication, resistance and interactions, legislation, probable solutions, changes
in practice and the concept of sustainability which would help guarantee the appropriate sale and rational use of antibiotics in Ethiopia.
University of Chinese Academy of Sciences, China
Cao Donghua is a PhD candidate from Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences and University of Chinese Academy of Sciences. Her Research Interest lies at the crossroads of chemistry and biology, and endeavors to discover novel active natural products from medicinal plant. She has published 3 papers in reputed journals
Meliaceous limonoids, characteristic chemical markers of the Meliaceae family, are natural products with both fascinating structures and potential bioactivities that have attracted interest from both natural products chemists and synthetic chemists in the past half century. As part of a continuing search for structurally interesting and biologically important limonoids from the Meliaceae family, the leaves and twigs of Trichilia sinensis collected from Xishuangbanna, Yunnan province of China were investigated. Trichilia sinensis Bentv, a shrub, is native to the south of China and Vietnam, and it has traditional applications for the treatment of several diseases such as abdominal pain caused by Ascaris lumbricoides, chronic osteomyelitis, scabies, and eczema in folk medicine. The three novel rearranged mexicanolide-type limonoids (Trichiliasinenoids A-C) with an unprecedented C-29-C-7 connecting carbon skeleton formed by migration of C-7 from C-6 to C-29 of a mexicanolide-type limonoid precursor were isolated from the leaves and twigs of Trichilia sinensis. Their structures were assigned by spectroscopic analysis, and the absolute conﬁgurations were determined by X-ray crystallography and CD calculation. A possible biosynthetic pathway of Trichiliasinenoids A was also proposed. The three new limonoids were evaluated for their cytotoxic activity against human myeloid leukaemia (HL-60), hepatocellular carcinoma (SMMC-7721), lung cancer (A-549), breast cancer (MCF-7), and colon cancer (SW480) cell lines by MTS assay. Trichiliasinenoid B showed cytotoxicity against HL-60 cells, SMMC-7721 with an IC50 value of 5.2 mM and 30.6 mM, respectively, whereas other limonoids were inactive and comparable to the cisplatin positive control (IC50: 1.1–17.3 m M).
Taiwan International Graduate program (TIGP), Taiwan
Muluye Melak Zenebe has completed his MSc at the age of 25 years from University of Gondar and now he is a PhD candidate at Taiwan international graduate program (TIGP), Taipei, Taiwan. He has published two papers in reputed journals.
Vernonia amygdalina (VA) is a tropical African plant of the Asteraceae family and is occasionally cultivated for its medicinal uses, which include as a treatment for diarrhea, skin wounds, fever mastitis and warms infection. The aim of this study is to isolate and elucidate the structure of some of the chemical constituents from the leaf of Vernonia amygdalina and its bioactivities. Methanol extract of Vernonia amygdalina, after repeated chromatography led to the isolation of a different compound, one of this compound (MM-4) is partially characterized based on the spectral data (IR, 1H NMR, 13C NMR, and DEPT) and Extracts from Vernonia amygdalina have been shown to have antimicrobial activity.
Quaid-i-Azam University, Pakistan
Zaka Un Nisa is working as a Faculty of Medicine in Quaid-i-Azam University in Islamabad, Pakistan.
Health care waste disposal is an alarming issue in these days. Improper disposal of injections and sharp wastes at open places exposes people to the risk of transmission of infectious diseases. Inappropriate methods of managing, treatment and disposal of health care waste can lead to an adverse effect on public health. This study highlights the unsafe disposal of injection and sharp waste in Rawalpindi, Pakistan. This study is conducted to explore the injection and sharp waste disposal practices at the community level clinics. In-depth scientific analysis study including the interviews of sanitary workers working in different community clinics is conducted. 65% claimed that they disposed of waste (syringes, swabs, dressings, needles) which they collected from clinics at open places and 35% stated that they dispose of waste in municipal bins. None of them has ever got training regarding injections and sharp waste disposal. Only 25% sanitary workers were aware of the hazardous effect of unsafe disposal of injection and sharp waste. 75% stated that they get injured one or more time while disposing of syringes. The reasons they stated of having injury were lack of time, lack of awareness regarding the transmission of infectious disease. There is an urgent need to develop safe and sustainable waste disposal method that is feasible at the clinic level. It is found that injections and sharp wastes from clinics are handled and disposed of together with domestic waste. It is also concluded that the duty of health care waste disposal is delegated to illiterate people who perform their duties without adequate knowledge and protective measures. Therefore, it is recommended that government and local health authorties should give immediate attention to this issue and setup a proper sustainable clinic waste disposal system.
Ewha Womans University College of Pharmacy, South Korea
Ji Hyun Park is working in Ewha Womans University College of Pharmacy at Seoul in South Korea.
Objective: This study aimed to identify the incidence of risk factors and the utilization of thromboprophylaxis for perioperative venous thromboembolism (VTE) in patients undergoing spine surgery using National Health Insurance claims data in Korea.
Methods: The incidence of VTE in adult patients with spine surgery was extracted from 2014 National Inpatient Sample dataset provided by the Health Insurance Review & Assessment Service (HIRA-NIS-2014), a sample of all patients using medical services in Korea. The association of patient and surgery procedure variables, including VTE prophylaxis were determined with multivariable logistic regression
Results: In 2014, total incidence of VTE was found to be 1.5% (314) among 20,900 spine surgeries in Korea. Multivariable logistic regression analysis identified several independent predictors of VTE, including age over 80, length of stay (over 10 days), vein diseases, cancer, prolonged surgery (over 2 hours), perioperative blood transfusion (over 2 liters), cardiovascular diseases, and respiratory diseases. Only 5.7% of total spine surgeries is provided with VTE prophylaxis.
Conclusion: Patients undergoing spine surgery in Korea represent a population at a higher risk for VTE, however, relatively less concerned by care providers. Understanding the risk factors associated with perioperative VTE in spine surgery may provide an opportunity for early intervention and risk stratification in this population.