Chihiro Sakai has completed her PhD from Graduate School of Human Development and Environment, Kobe University. Currently, while working as a pharmacist at Gifu Pharmaceutical University pharmacy, she is engaged in research on medicine education for young people and work improvement of community pharmacists.
Education for Medicines was integrated into the Japanese junior high school health and physical education (HPE) guidelines in 2012, in tandem with revisions to the Course of Study. However, according to the survey we conducted targeting high school students in Gifu prefecture, it became clear that there were many students who think that they have never attended "Education for Medicines". In this research, we survey knowledge, behavior and attitudes about medicines among high school first graders in Japan. Furthermore, we clarify the relationship between awareness of taking the class of "Education for Medicines" and behavior, attitudes and knowledge about medicines. A questionnaire survey was administered at 81 high schools throughout Japan from May to August 2017. We received valid responses from 17,437 students (8,205 males, 9,232 females). Responding to a question on whether they were aware of the class of "Education for Medicines," 29.5% of the students answered “Yes,” 45.2% “I don’t know,” and 24.9% “No.” Students with awareness of the class tended to have more knowledge and take favorable attitudes and behaviors than non-aware students. Furthermore, students with positive attitude were likely to take medicines appropriately. The results of this survey suggest that ongoing implementation of the class of "Education for Medicines" promotes students to acquire knowledge and favorable behavior and attitudes about medicines. In future, further development of both the classes and the instructions are required, to accomplish the purpose given in the Course of Study.
Leong-Perng Chan is associated doctor at Department of Otolaryngology-Head and Neck Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University. He focus on otorhinolaryngology-head and neck surgery, Squamous cell carcinoma of the head and neck, and Oncology filed.
8-Hydroxyquinoline derivatives have highly sensitive fluorescent chemosensors for metal ions, which are associated with a wide range of physiological activities, including anti-tumor, anti-microbial, anti-HIV-1, anti-oxidant activities. A novel 8-hydroxyquinoline derivative, Feq3, was synthesized. Oral cancer is generally detected in the late stages when the cancer has advanced, and therefore has a poor prognosis and survival rate. Therefore, effective chemotherapy agents are required to address this public health issue. This work is the first to identify the inhibition of cell growth by Feq3 and to examine its effects on cell cycle distribution and apoptosis in oral cancer cells. Squamous cell carcinoma (SCC) of oral cavity is of malignant tumors. Treatment of SCC25 cells with Feq3 increased expression of TNF-related apoptosis inducing ligand receptors (TRAIL-Rs), and enhanced the susceptibility of cells to TRAILs, and involved signal cascades caspase-3 effectors of apoptosis. This study of molecular mechanisms of the anti- oral cancer effects of Feq3 in SCC25 cells suggests that Feq3 can be applied as a chemopreventive agent for human oral cancer.