Gautam Sethi
National University of Singapore, Singapore
Title: STAT3 as a molecular target for prostate cancer prevention and therapy
Biography
Biography: Gautam Sethi
Abstract
Prostate cancer (PCa) is one of the most commonly diagnosed cancers worldwide. Currently available therapies for metastatic PCa are only marginally effective; hence novel treatment modalities are urgently required. Our group has recently analyzed the potential anticancer effects of nimbolide (NL), a limonoid triterpene derived from Azadirachta indica, against PCa cell lines and in vivo models. Data from the in vitro studies indicated that NL could significantly inhibit cell viability, induce apoptosis and suppress cellular invasion and migration. Interestingly, NL also abrogated STAT3 activation, and this effect was found to be mediated via increased accumulation of reactive oxygen species (ROS) due to GSH/GSSG imbalance. NL administration also significantly suppressed the tumor growth and metastasis in transgenic PCa mouse model without any significant adverse effects. Overall present studies demonstrate critical role of GSH/GSSG imbalance-mediated ROS production contributing to STAT3 inhibitory and tumor suppressive effect of NL in PCa.
