Paresh J Wadhwani
P Wadhwani College of Pharmacy, India
Title: Evaluation of effect of Nerium oleander in diabetic neuropathy
Biography
Biography: Paresh J Wadhwani
Abstract
Present investigation evaluates the effect of hydro alcoholic extract of Nerium oleander (NO) in the management of diabetic neuropathy. Diabetic neuropathy was induced by streptozotocin (STZ) [60 mg/kg, i.p.]. Confirmation of neuropathy various parameters like glucose level, analgesic response, muscle coordination, and intestinal transit were checked. Loss of muscle coordination were checked by rata road apparatus and Swimming Endurance Test, whereas declination of analgesic response was done by tail flick response and writhing reflex. There was significant (p<0.01) improvement in analgesic response like as well as muscle coordination response was observed in the rats treated with the Hydro ethanoilc extract of NO compared to negative control group. The given study concluded that by improving the analgesic response, muscle coordination and intestinal transit NO is beneficial for the management of DN.