Faten Zahran Mohamed
Zagazig University, Egypt
Title: Antidiabetic activity of Caffeic acid and 18β-glycyrrhetinic acid and its relationship with the antioxidant property
Biography
Biography: Faten Zahran Mohamed
Abstract
This study was performed to investigate the antidiabetic effect of caffeic acid and 18β-glycyrrhetinic acid against diabetic rats. In this experiment, the animals were divided into five groups. Group I: Normal rats. Group II: Diabetic control rats. Group III: Diabetic rats treated with 18β-glycyrrhetinic. Group IV: Diabetic rats treated with caffeic acid. Group V: Diabetic rats treated with 18β-glycyrrhetinic and caffeic acid. Fasting blood glucose, insulin, glutathione reductase (GR), glutathione peroxidase (GPx), total antioxidant (TAO), catalase (CAT), and superoxide dismutase (SOD) and malondialdehyde (MDA) were analyzed. Results: Fasting blood glucose and MDA were significantly increased, whereas insulin, GR, GPx, TAO, CAT, and SOD were decreased significantly in diabetic rats. Though the diabetic rats treated with caffeic acid and 18β glycyrrhetinic acid individual exerts beneficial effects in all the biochemical parameters in diabetic rats. The combined treatment with caffeic acid and 18β-glycyrrhetinic acid normalized all the above-mentioned biochemical parameters in diabetic rats. Our findings demonstrated that 18β-glycyrrhetinic acid and caffeic acid either used individually or in combination to diabetic rats has antidiabetic effect and a good antioxidant property. From the results, the combined dose of 18β-glycyrrhetinic acid and caffeic acid to diabetic rats showed the promising effect and antioxidant property compared to individual treatments.