Muhammad Imran Khan
The Islamia University of Bahawalpur, Pakistan
Title: Ultrasonic processor technique as a green preparation approach for Diacerein loaded niosomes
Biography
Biography: Muhammad Imran Khan
Abstract
Niosomes have potential to act as a drug carrier with improved solubility and dissolution profile and, hence, enhanced bioavailability. In this study, the feasibility of less utilized ultrasonic processor (UP) technique for niosome production was evaluated as an alternative green preparation method instead of thin film hydration (TFH) process. Also effect of different surfactant systems on niosomes’ characteristics were analyzed with diacerein as a model drug. The studied surfactant systems were Span 20, Pluronic L64 and their mixture (Span 20 and Pluronic L64). Niosomes were prepared using both the TFH technique, which involves organic solvents i.e. chloroform and methanol, and the UP technique. Both the production techniques produced well defined spherical vesicles, while the UP technique produced smaller and more monodisperse niosomes than TFH. The entrapment efficiencies with the UP method were little lower than with TFH, but still at a feasible level. All the niosomal formulations released diacerein faster than the dissolution of pure drug, and the drug release rates from the niosomes produced by the UP method were higher than from the TFH produced niosomes. With UP technique the optimum process conditions for small niosomal products with low PDI values and high entrapment efficiencies were obtained when 70% amplitude and 45 minutes sonication time were used. The overall results demonstrated the potency of UP technique as an alternative fast, cost-effective and green preparation approach for niosome production.