Ahmad Nazrun Shuid
Universiti Kebangsaan Malaysia, Malaysia
Title: Targeted deliveries of Tocotrienol and Statin accelerate healing of osteoporotic fracture
Biography
Biography: Ahmad Nazrun Shuid
Abstract
Combination of oral tocotrienol and oral statin has been shown to be effective in the prevention of osteoporosis. In this study, tocotrienol and statin were combined with their carriers and delivered directly to the fracture site (controlled drug delivery system) of osteoporosis fracture model. Forty-eight Sprague-Dawley female rats were divided into 6 groups. The first group was sham-operated (SO), while the others were ovariectomized. After two months, the right tibiae of all rats were fractured at proximal upper third area and fixed with plates and screws. The SO and ovariectomized-control rats (OVxC) were given two single injections of carriers. The estrogen group (OVx+ERT) was given daily oral gavages of Premarin®. The Lovastatin treatment group (OVx + Lov) was given a single injection of lovastatin particles. The tocotrienol group (OVx + TT) was given a single injection of tocotrienol particles. The combination treatment group (OVx+ Lov+ TT) was given two single injections of lovastatin particles and tocotrienol particles. After 4 weeks of treatment, the fractured tibiae were dissected out for micro-CT and biomechanical assessments. Only combined treatment group (OVx+ Lov+ TT) showed significantly better callous structure but all treatment groups showed better callous strength than OVxC group. In conclusion, combined lovastatin and tocotrienol may promote better fracture healing of osteoporotic bone.