6^th Asia-Pacific Pharma Congress

Biography

Biography: Abbah Okpachi Christopher

Abstract

Benign prostate hyperplasia (BPH) is becoming a leading cause of morbidity and mortality in human male adults aged 50 years and above. The study was set out to undertake phytochemical screening and proximate analysis of the pulp of A. muricata fruit - soursop; to determine the acute toxicity of the fruit pulp extract and its effect on male albino Wistar rats with concurrent induction of experimental BPH. All rats were dosed aqueous A. muricata extract orally. Tumor was induced with exogenous Testosterone propionate:Estradiol valerate at 300µg:80µg/kg b.w. respectively in olive oil as vhicle, administered subcutaneously in the inguinal region of the rats on alternate days for 21 days. Administration of the fruit pulp at graded doses up to 5000mg/kg resulted in no lethality even after 72 hours. Results from tumor studies revealed that the administration of the fruit extracts significantly (p<0.05) reduced the relative prostate weight of the Test Group compared with the Hormone Control. Treatment with vehicle, soursop and vehicle with soursop caused no significant (p>0.05) change in prostate size, compared with Test Group. Also, treatment with A. muricata fruit extract significantly decreased (p<0.05) serum prostate specific antigen in Test Group compared with Hormone Control. The preventive property of soursop against experimental BPH was corroborated by histological evidence in this study. The study concludes that A. muricata fruit holds a great potential for benign prostate tumor prevention and, possibly, management.