Tian Hai-Yan
Jinan University, China
Title: Novel bufadienolides with rearranged skeletons from traditional chinese medicine ChanSu
Biography
Biography: Tian Hai-Yan
Abstract
Toad venom, locally called ChanSu, is the secretion of the postauricular and skin glands of toads Bufo bufo gargarizans Cantor or B. Melanostictus Schneider, has been widely used as a traditional Chinese medicine in the treatment of superficial infection, odontalgia and skin cancer, and is also useful as a chemical weapon against the natural enemies of toads. During our system chemical investigation of ChanSu, three novel rearranged bufadienolides, bufogargarizins A-C (1-3) were isolated from the CH2Cl2 extraction of ChanSu. Their structures with absolute configurations were elucidated by spectroscopic analysis, single crystal X-ray diffraction, and computational calculations. Compounds 1, 2 and 3 had unprecedented 7/5/6/5/6, 5/7/6/5/6 and 6/7/6/5/6 ring systems, respectively, instead of the 6/6/6/5/6 skeleton presented in common bufadienolides. Our proposed biosynthetic pathways as well as the identification of the key intermediates supported that they were biosynthesized from the normal bufadienolides.
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