Waddah Faroug Hassan
National Medicine & Poisons Board-Sudan, Sudan
Title: Gum arabic acacia for manufacturing of tablet & pellets coating materials
Biography
Biography: Waddah Faroug Hassan
Abstract
Gum arabic is a complex, loose aggregate of sugars and hemicelluloses composed of Arabic acid nucleus connected with calcium, magnesium, potassium besides Arabinose, Galactose, and Rhamnose. Gum Arabic is stable flexible material. This study aimed to use gum Arabic in manufacturing of Tablet coating material using water and plasticizer to add elasticity and flexibility. Gum Arabic acacia used in (10%), concentration in a pilot small coating machine with an inlet temperature 400c, and spraying rate 10 mls every 5 minutes on the top of Placebo tablet-bed while continuous drying. Gum: water ratio and plasticizer was determined by trial and error method to obtain the optimum level for the final coat characteristic. Physical tests were done for the tablets before-and after the process. An accelerated stability study for three months was done.
The result showed the optimum concentration ratio was 10% Gum arabic with 1% plasticizer. While other ratio variations showed cracking, and roughness in the surface. Physical examination ended to satisfying coat appearance with elegant, smooth picture. Gum Arabic is suitable material for tablets coating. The final property varies with the change in ratio of formula. Colors and anti-transparency additives are required for technological identification & customers’ needs. The ratio of 10:1 is the optimum to be adopted in manufacture film coating. (Patent 3422–Ministry of Justice-Republic of Sudan) – (Suad Alkarib-Karary University).