10^th Asia-Pacific Pharma Congress May 08-10, 2017 Singapore

Biography:

Bienvenido S Balotro, RPh, MBA, MS, is an Assistant Professor of the Department of Industrial Pharmacy, College of Pharmacy, University of the Philippines Manila where he has taught pharmaceutical dosage form and drug delivery systems, pharmaceutical product development, and pharmaceutical marketing. Paola Marie Sabban, RPh, MS, is a Regulatory Affairs Associate at Pfizer (Phils.) Inc. She finished her Master of Science degree (Industrial Pharmacy track) at the University of the Philippines Manila, College of Pharmacy.

Abstract:

Background: Verapamil hydrochloride is a commonly prescribed drug in the management of hypertension, angina, and cluster headache prophylaxis. Verapamil hydrochloride suffers from the disadvantage of low bioavailability because of extensive hepatic metabolism (only 10% to 20% becomes bioavailable) and short half-life (2 to 4 hours). As a result, it requires frequent dosing of the drug leading to the problem of noncompliance in patients and alternating over and under doses of the drug. A method of circumventing hepatic first pass effect is by making the drug particle microsized(<10µm) and lipophilic.

Objectives: The aim of this study was to characterize the optimized microparticles of Verapamil hydrochloride entrapped in Poly (lactide-co-glycolide) (PLGA) (Verapamil HCl-PLGA) prepared through solvent displacement method followed by lyophilization.

Significance: This study sought to contribute to the improvement of the dosage form of Verapamil HCl by the application of polymeric drug delivery system. Through polymeric drug formulation, the low bioavailability due to hepatic first-pass effect is addressed by the transport of hydrophobic polymeric microparticles (size of <10µm) to the lymphatic system instead of the hepatic portal transport, therefore, avoiding extensive hepatic metabolism.

Methodology: The Verapamil HCl-PLGA microparticles were prepared through solvent displacement method followed by lyophilization. The optimization parameters for the formulation include particle size, polydispersity index, zeta potential, and entrapment efficiency. The optimized final formulation was further characterized based on percent (%) particle recovery, redispersibility, percent (%) drug loading, drug release kinetics, and morphology.

Results:  Based on the analysis of the data from solvent displacement method, increasing The PLGA 75:25 concentration resulted to an increase in the particles size, polydispersity index and entrapment efficiency, and a decrease in zeta potential; while the increase in Poloxamer 188 concentration led to a decrease in zeta potential and an increase in the entrapment of the drug; lastly, the increase in the pH of the non-solvent phase resulted to an increase in particle size. The addition of sucrose, led to a unfavorable increase in the particle size and polydispersity index, and a decrease in zeta potential and entrapment efficiency after lyophilization. The final product of the process was a heterogenous sized (<10µm) irregularly shaped particles (fragment-like), with an acceptable particle recovery, redispersibility, and percentage (%) drug loading, but poor release kinetic property (non-linear and decreasing concentration over time).

Conclusion:  The Verapamil HCl-PLGA microparticles prepared through solvent displacement method followed by lyophilization were able to meet the conditions noted by Chu and Lui (2008) for lymphatic transport: entrapment in a lipophilic polymer in terms of particle size requirement (<10µm).

Biography:

Dr Allen Lai received his Ph.D. and MPA, from Lee Kuan Yew School of Public Policy, National University of Singapore, M.Sc. (Preventive Medicine) from National Taiwan University and M.D. from Chung Shan Medical Dental University, Taiwan. He was the principal consultant at IMS Health Asia, a leading global information and technology services company in the healthcare industry, and the director of Institute of Health Economics & Management and the academic director of MSc Management of Health Industries in ESSEC Business School. He was also the attending physician in National Taiwan University Hospital and Taipei City Hospital. He has authored more than 40 articles in peer-reviewed journals. He holds several high key profile roles as President of ISPOR, Singapore Regional Chapter and concurrently the Consultant in Urology, and Advisor for Ministry of Health and Social Welfare, Taiwan. 

Abstract:

Coupled with the availability of molecular therapeutic targeting genomically defined population, next-generation sequencing (NGS) based multiplexed genomic profiling has created a growing interest among cancer specialists and pharmaceutical companies. Among all, using the adequate technology platform to identify the right genomic biomarker and provide treatment options is pivotal in drug discovery and development, as well as clinical decision making. There is little doubt that the interest has been prompted by advances in our understanding of disease, improvements in NGS platforms and accumulating paradigms of benefit. However, such shift towards precision medicine requires significant changes in healthcare systems, such as regulatory issues, multidisciplinary collaboration in a traditionally conservative and siloed health system. There is much opportunity to pioneer the development of precision medicine, particularly in the growing markets of Asia, where there is a dearth of expertise and quality and which many large organizations have as secondary areas of development. In this talk, Dr. Lai will walk the audience through the evolution of cancer precision medicine in the search of biomarkers, and the impact to cancer management in Asia, as well as business growth potential.

Biography:

Mary Suja R is director of William Research Centre at Nagercoil, India. 

Abstract:

Breast Cancer is the leading cause of death in women worldwide among other types of cancers. The present investigation was mainly focused on the scientific analysis to assess the qualitative and quantitative phytochemical constituents, antioxidant potential, cytotoxic, antiproliferative and apoptotic effect of Traditional Siddha Breast Cancer Medicine. To create an awareness regarding the value of Siddha Medicine and to utilize the cheapest source of Traditional Siddha Breast Cancer medicine to relapse the patient from breast cancer without side effects. The plant materials required for the formulation of medicines were collected from the hills and hill locks of Molliadi and other ingredients were procured from Siddha raw drug stores. The herbal formulations were prepared as prescribed in the Palm leaf parchments by my Grandpa and Ancestors, Traditional Siddha Practitioners, India.  The scientific analysis of Siddha Breast Cancer medicines and case reports highlight the effect of medicine to relapse the patient from breast cancer. This research work makes the society to believe that treatment is also possible without any significant side effects. Apparently, the promising active principles and underlying mechanism by which this activity was exhibited need to be further investigated. 

Biography:

P Rajasulochana is working as an Associate professor at department of Genetic Engineering in Bharath University located at Chennai, India.

Abstract:

Marine environment is rich source of bio-diversity. Algae are available in macro and micro level. These algae are available in various types like green algae, brown algae and red algae. One of the green algae is spirulina, rich source of proteins. In brown algae, padina species are important for different antibacterial, antiviral and antifungal activity. Red algae, kappaphycus  alvarezii  have various applications like neutraceutical, pharmaceutical and bioactive related effects. This algae have a lot of bioactive compounds which shows different activites like antibacterial, antifungal and antiviral activity.    Samples were collected from rameshwaran region,tamilnadu ,india. during the month of june. The samples were air dried and sun shaded for seven days. Kappaphycus (red algae) seaweed species were tested for their antibacterial activities using disc diffusion method. The species have primary and secondary metabolites, both metabolites show antimicrobial activities against different pathogens. Many bromo-compounds are identified for antimicrobial activites. Pseudomaonas flouresences, staphylococcus aureus, vibriochloera and proteus mirabilis are collected from madras university, Chennai. We subjected  kappaphycus  alvaerezii sample to identify the antibacterial activity using disc diffusion method. This review states that the red algae species have antibacterial activity against different bacterial species.

Biography:

B Saritha is working as an Assistant professor in the department of Plant Biology and Plant Biotechnology at Justice Basheer Ahmed Sayeed College for Women, Teynampet in Chennai, India.

Abstract:

Pisonia alba leaf were collected from five different diverse places of Tamilnadu to Analysis the Antioxidant activity, Total Phenol and Flavonoid content of leaf extraction from various solvents( Aqueous, Ethanol, Petroleum ether, Chloroform, and acetone). Butylated Hydroxy Toluene (BHT), Gallic acid (GA) and Quercetin (Q) were taken as standard in case of antioxidant activity, phenol and flavonoid content respectively. The leaf extracts were evaluated for antioxidant activities by DPPH (1,1–diphenyl-2-picryl- hydrazyl) radical scavenging assay. The Maximum antioxidant activity was found in ethanolic leaf extract (65.7%) from Thiruvannamalai as compare to other accessions. Total phenol and flavonoid contents were quantitatively estimated. Total phenolic content measured by Folin-Ciocalteau method varied from 9.64 to 29.72 mg/Gallic Acid Equivalents (GAE)/g and the total flavonoid contents as measured by aluminum chloride method varied from 6.32 to 12.36 mg /Quercetin Equivalents (QE)/g.The ethanolic leaf extract of pisonia alba was found maximum in total phenol and flavonoid contents were 12.6 mg/ GAE /g and 7.5 mg QE /g respectively.

Biography:

Ibrahim H Kankia is a PhD Research Student in Molecular and Genetic Medicine at University of Abertay Dundee, United Kingdom. He is from Nigeria, the most populated country in Africa; He has keen interest in research and teaching. He started his PhD in September 2014 and he is basically working on the novel activators and inhibitors of NRF2 to improve life.

Abstract:

Luteolin enhances the increased in normal breast cell growth through NRF2 activation, although the exact mechanism of this activation is still unclear. The HER1 is one of the members of EGFR family which regulate the normal cellular proliferation, differentiation and maintenance. These receptors dimerize upon ligand binding, leading to activation of their tyrosine kinase domain. This subsequently led to the phosphorylation of their tyrosine residues in the intracellular domain. Nuclear factor (NRF2) is a transcription factor that regulates the expression of a battery of many genes including cytoprotective and detoxifying genes. Abnormal expression of both HER1 and NRF2 are reported in tumour initiation and studies have implicated both NRF2 and HER family in numerous cancers. In this study, we demonstrated that luteolin activated the NRF2 activity, which led to maintenance of HER1 protein expression and increased in cell growth of MCF10 cells. Additional investigation revealed that luteolin could lead to transcriptional activation of HER1 promoter activity by activating the NRF2 activity in the HER1 promoter region. Furthermore, activation of NRF2 by luteolin led to increase in total glutathione and other enzymes such as HO-1 and pAKT in the cell line used. Taken together, these data suggest that luteolin may activate the cell proliferation of normal breast cells through NRF2-mediated activation of HER1 expression and could be a novel avenue that luteolin induced NRF2 activation, which lead to increase normal breast cell growth.

Biography:

Bienvenido S Balotro, RPh, MBA, MS, is an Assistant Professor of the Department of Industrial Pharmacy, College of Pharmacy, University of the Philippines Manila where he has taught pharmaceutical dosage form and drug delivery systems, pharmaceutical product development, and pharmaceutical marketing. Paola Marie Sabban, RPh, MS, is a Regulatory Affairs Associate at Pfizer (Phils.) Inc. She finished her Master of Science degree (Industrial Pharmacy track) at the University of the Philippines Manila, College of Pharmacy.

Abstract:

Background: Verapamil hydrochloride is a commonly prescribed drug in the management of hypertension, angina, and cluster headache prophylaxis. Verapamil hydrochloride suffers from the disadvantage of low bioavailability because of extensive hepatic metabolism (only 10% to 20% becomes bioavailable) and short half-life (2 to 4 hours). As a result, it requires frequent dosing of the drug leading to the problem of noncompliance in patients and alternating over and under doses of the drug. A method of circumventing hepatic first pass effect is by making the drug particle microsized(<10µm) and lipophilic.

Objectives: The aim of this study was to characterize the optimized microparticles of Verapamil hydrochloride entrapped in Poly (lactide-co-glycolide) (PLGA) (Verapamil HCl-PLGA) prepared through solvent displacement method followed by lyophilization.

Significance: This study sought to contribute to the improvement of the dosage form of Verapamil HCl by the application of polymeric drug delivery system. Through polymeric drug formulation, the low bioavailability due to hepatic first-pass effect is addressed by the transport of hydrophobic polymeric microparticles (size of <10µm) to the lymphatic system instead of the hepatic portal transport, therefore, avoiding extensive hepatic metabolism.

Methodology: The Verapamil HCl-PLGA microparticles were prepared through solvent displacement method followed by lyophilization. The optimization parameters for the formulation include particle size, polydispersity index, zeta potential, and entrapment efficiency. The optimized final formulation was further characterized based on percent (%) particle recovery, redispersibility, percent (%) drug loading, drug release kinetics, and morphology.

Results:  Based on the analysis of the data from solvent displacement method, increasing The PLGA 75:25 concentration resulted to an increase in the particles size, polydispersity index and entrapment efficiency, and a decrease in zeta potential; while the increase in Poloxamer 188 concentration led to a decrease in zeta potential and an increase in the entrapment of the drug; lastly, the increase in the pH of the non-solvent phase resulted to an increase in particle size. The addition of sucrose, led to a unfavorable increase in the particle size and polydispersity index, and a decrease in zeta potential and entrapment efficiency after lyophilization. The final product of the process was a heterogenous sized (<10µm) irregularly shaped particles (fragment-like), with an acceptable particle recovery, redispersibility, and percentage (%) drug loading, but poor release kinetic property (non-linear and decreasing concentration over time).

Conclusion:  The Verapamil HCl-PLGA microparticles prepared through solvent displacement method followed by lyophilization were able to meet the conditions noted by Chu and Lui (2008) for lymphatic transport: entrapment in a lipophilic polymer in terms of particle size requirement (<10µm).

Biography:

Abdeen Mustafa Omer (BSc, MSc, PhD) is an associate researcher at Occupational Health Administration, Ministry of Health and Social Welfare, Khartoum, Sudan. He has been listed in the book WHO’S WHO in the World 2005, 2006, 2007 and 2010. He has published over 300 papers in peer-reviewed journals, 200 review articles, 7 books and 150 chapters in books.

Abstract:

The strategy of price liberalisation and privatisation had been implemented in Sudan over the last decade, and has had a positive result on government deficit. The investment law approved recently has good statements and rules on the above strategy in particular to pharmacy regulations. Under the pressure of the new privatisation policy, the government introduced radical changes in the pharmacy regulations. To improve the effectiveness of the public pharmacy, resources should be switched towards areas of need, reducing inequalities and promoting better health conditions. Medicines are financed either through cost sharing or full private. The role of the private services is significant. A review of reform of financing medicines in Sudan is given in this article. Also, it highlights the current drug supply system in the public sector, which is currently responsibility of the Central Medical Supplies Public Corporation (CMS). In Sudan, the researchers did not identify any rigorous evaluations or quantitative studies about the impact of drug regulations on the quality of medicines and how to protect public health against counterfeit or low quality medicines, although it is practically possible. However, the regulations must be continually evaluated to ensure the public health is protected against by marketing high quality medicines rather than commercial interests, and the drug companies are held accountable for their conducts.

Biography:

Anil Dewani is working at department of Quality Assurance in Pataldhamal Wadhwani College of Pharmacy in Yavatmal, India.

Abstract:

A novel, simple and MS compatible high-performance liquid chromatography (HPLC) method is reported for the simultaneous estimation of Ilaprazole (ILA) and Glimepiride (GLM) in rat plasma. The bioanalytical procedure involves extraction of ILA, GLM and Internal Standard (IS) from rat plasma with a solid phase extraction (SPE) process. The chromatographic analysis was performed on Waters-600 system using a isocratic mobile phase comprising methanol:water (80:20 % v/v) with pH of water modified to 3 using formic acid at a flow rate of 1.0 mL/min and Kinetex C₁₈ column maintained at 30 ± 1 °C. The signals were monitored using a PDA detector set at 225 nm. IS,  Ilaprazole and Glimepiride eluted at 2.04, 4.7 and 7.4 min respectively and the total run time was 10 min. Method validation was performed as per US Food and Drug Administration guidelines and the results met the acceptance criteria. The calibration curve was linear over a concentration range of 10–600 ng/mL (r² = 0.999). The intra- and inter-day precisions for ILA and GLM were (%RSD values) in the range of 1.52–9.74 and 1.52–11.76%, respectively, in rat plasma. The method was successfully applied in pharmacokinetic studies followed by oral administration of GLM and ILA in rats.

Biography:

Phuong Thuy Viet Nguyen has completed her PhD in Medicinal Chemistry at the University of Wollongong, Australia in 2015. She is currently a lecturer in Faculty of Pharmacy, University of Medicine and Pharmacy at Hochiminh city, Vietnam. She is interested in computer-aided drug discovery and development. Her research focuses on antiviral drug discovery, using in silico approaches such as molecular docking, molecular dynamics simulations and binding free energy in developing the inhibitors for the viruses.

Abstract:

Ebola virus (EBOV) is a fatal virus that causes severe hemorrhagic fever in human and animals. However, there is currently no FDA-approved drug for treating Ebola virus infection. Identification of potential inhibitors for Ebola virus has gained much attention of medicinal chemists in the last few years. Although few lead compounds were identified, the drug discovery for Ebola virus is significantly more challenging. In this study, in silico approaches were applied to explore potential inhibitors for EBOV infection. Initally, four protein targets for EBOV were identified through their important roles in viral pathogenesis and disease, namely VP24 (PDB id: 4MOQ), VP30 (PDB id: 5DVW), VP35 (PDB id: 3FKE), và VP40 (PDB id: 1H2C), respectively. The ligands were taken from some drugs which are in clinical testings from other anti-viruses potential compounds. Through blind dockings and focused dockings, the potential inhibitors and binding sites were discovered for different protein targets of EBOV. The docking results of the trial drugs are consistent with the experiment data. In the group of other potential compounds, there were some ligands which had abilities to well-bind with Ebola proteins such as Silybin (-9.5 kJ.mol-1), Harringtonine (-8.0 kJ.mol-1), Homoharringtonine (-8.3 kJ.mol-1), Chat 5 (-8.2 kJ.mol-1). Among these ligands, after screening through Lipinski 5 rules, Silybin was the only suitable one which could be used as lead compounds for EBOV drug discovery. This study provided helpful information to considerably assist in drug discovery of antiviral agents for Ebola virus.

Biography:

Faten Zahran Mohamed  has completed her PhD at the age of 30 years from Ein Shams University and postdoctoral studies from Ein Shams University School of Science. She is a professor in department of biochemistry, Faculty of Science in Zagazig University, Egypt. She has published more than 123 papers in reputed journals. 

Abstract:

This study was performed to investigate the antidiabetic effect of caffeic acid and 18β-glycyrrhetinic acid against diabetic rats. In this experiment, the animals were divided into five groups. Group I: Normal rats. Group II: Diabetic control rats. Group III: Diabetic rats treated with 18β-glycyrrhetinic. Group IV: Diabetic rats treated with caffeic acid. Group V: Diabetic rats treated with 18β-glycyrrhetinic and caffeic acid. Fasting blood glucose, insulin, glutathione reductase (GR), glutathione peroxidase (GPx), total antioxidant (TAO), catalase (CAT), and superoxide dismutase (SOD) and malondialdehyde (MDA) were analyzed. Results: Fasting blood glucose and MDA were significantly increased, whereas insulin, GR, GPx, TAO, CAT, and SOD were decreased significantly in diabetic rats. Though the diabetic rats treated with caffeic acid and 18β glycyrrhetinic acid individual exerts beneficial effects in all the biochemical parameters in diabetic rats. The combined treatment with caffeic acid and 18β-glycyrrhetinic acid normalized all the above-mentioned biochemical parameters in diabetic rats. Our findings demonstrated that 18β-glycyrrhetinic acid and caffeic acid either used individually or in combination to diabetic rats has antidiabetic effect and a good antioxidant property. From the results, the combined dose of 18β-glycyrrhetinic acid and caffeic acid to diabetic rats showed the promising effect and antioxidant property compared to individual treatments.

Biography:

Md Shariful Islam is Faculty of Life Sciences and working in the Department of Biotechnology and Genetic Engineering, Mawlana Bhashani Science and Technology University, Bangladesh. Md. Shariful Islam has published many articles. His research interests are Biochemistry, Applied biochemistry, Physiology, Cellular Biochemistry, and Biotechnology. 

Abstract:

Leonurus sibiricus is a herbaceous plant found in many countries in Asia and America. This plant is widely practiced as a remedy for the treatment of diabetes, menstrual irregularities, and bronchitis. The approval of therapeutic implications of any drugs depends on the well characterized mode of actions of the compounds. The bioactive compounds like diterpenes, triterpenes, flavonoids and phenolic acids in Leonurus sibiricus show analgesic, antiinflammatory, anti-oxidant, anti-atherogenic and anti-hemorrhagic, anti-diabetic, antibacterial and allelopathic potency. Interestingly, the expression level of some genes is altered by the crude extract treatments, which are effective against cancers, diabetes and cardiovascular diseases where the molecular mechanisms are yet to be explored. Intriguingly, the extracts significantly induce nitric oxide production by endothelial nitric oxide synthase, a signaling molecule of vasodilation in combination with interferon-γ indicating positive effect on atherosclerosis. Further investigations are required to unlock the effects of bioactive compounds found in extracts at clinical settings.

Biography:

Nashwa Masnoon is a PhD student at the University of South Australia (UniSA) and a pharmacist at the Royal Adelaide Hospital (RAH). She graduated from Bachelor of Pharmacy with Honours at UniSA in 2013. Her research experiences include developing a dose adjustment tool for warfarin, evaluating patient retention of information after warfarin counselling by clinical pharmacists and assessing the use of different psychotropic medications in a mental health hospital. As a result of having worked at the Repatriation General Hospital, Glenside Mental Health Hospital and the RAH, her areas of interest and publications are in geriatric medicine, psychotropic polypharmacy and the quality use of medicines. Nashwa’s PhD project focuses on optimising medication use in the older population. She is also involved in medication management for clients with disabilities. Nashwa received the Student Leadership Award in 2013 for mentoring students and continues teaching undergraduate students and interns in hospital pharmacy. 

Abstract:

Multimorbidity and the use of multiple medicines, commonly referred to as polypharmacy, is common in the older population. However there is no universal definition of polypharmacy. Three systematic reviews of polypharmacy definition, assessment tools and their associations with clinical outcomes were conducted using Medline/Embase databases of articles in English between 2000-2016 which i) defined polypharmacy ii) explored tools that assess polypharmacy and iii) examined clinical outcomes. A total of 112 articles were identified for polypharmacy definitions. While definitions ranged from two or more, to 11 or more medications daily, the most commonly reported definition was five or more medications daily (n=51, 45.5%). Few studies (6.3%) distinguished between appropriate and inappropriate polypharmacy but this distinction was not based on the pharmacology of medications. A total of 26 polypharmacy tools were identified and divided into two broad categories; tools with a scoring system (n=8) such as the Drug Burden Index and tools that do not provide a score (n=18) but criteria for appropriate or inappropriate prescribing such as the Beers Criteria. Out of the 26 tools identified, 50% were associated with at least one clinical outcome. Three of the tools were associated with mortality, hospitalisation and functional decline. Studies have used the number of medicines to define polypharmacy which may not be clinically relevant without considering the pharmacology of medications involved. There is a need for tools which consider polypharmacy at an individualised-patient level to provide tailored guidance around optimising appropriate therapy and deprescribing inappropriate therapy to improve health outcomes.   

Biography:

Ch Supriya has her expertise in evaluation and passion in improving the health and wellbeing. Her open and contextual evaluation model based on improving the activity of crude drugs by increasing the bio availability creates new pathways for improving healthcare.

Abstract:

The flavonoids comprise a large class of low-molecular-weight plant metabolites ubiquitously distributed in food plants. These dietary antioxidants exert significant antitumor, antiallergic, and anti-inflammatory effects. Quercetin is a naturally occurring chemical found in fruits and vegetables. Flavonoids such as quercetins, are antioxidants, antibacterial and anti inflammatory agents. The molecular mechanisms of their biological effects remain to be clearly understood. Flavonoids have more therapeutic activity and less solubility. So, its activity can be enhanced through enzymatic conjugation or sulfation by Arylsulfotransferases or by other hydrophilic enzymes. In the present work, we have taken Papain conjugated Quercetin enzyme to increase its solubility and bioavailability. Enzyme conjugation was analysed by HPLC method. HPLC at 255nm using an isocratic mobile phase (60:40, acetonitrile: 0.1% acetic acid). HPLC was evaluated through high accuracy, precision, recovery and that enzymatic conjugation may enhance the antibacterial, analgesic activity and antifungal activity was found to be increased. 

Biography:

Ebrahim Doostzadeh is a PhD student at Department of Technology Management, in Roudehen Branch, Islamic Azad University at Tehran, Iran.

Abstract:

Objectives: The pharmaceutical market is a complex market due to its complicated supply chain and the extent of government regulations in all aspects of the trade life cycle of drug development. Considering the importance of pharmaceuticals for society and the relevant trend of globalization, managing pharmaceutical industry effectively and efficiently is vital, particularly in developing countries. The present study determines factors affecting the development of the Iranian pharmaceutical industry, based on pharmaceutical mangers` point of view.

Methods: In this study we assessed Managers` perspective about the internal and external key factors affecting the development of pharmaceutical industry. Finally, their perspective about the solutions for development of pharmaceutical industry was assessed. Accordingly, a self-designed questionnaire was sent to 65 managers at Tamin Pharmaceutical Investment Company (TPICO)¹, of which 51 questionnaires were answered by the managers.

Result: Most managers believed generic scheme reflect negatively on the development of the pharmaceutical industry, and that external factors have a great impact on its improvement.  They believe that branded- generic transition along with supporting regulations, investment in Research and Development (R&D), and joint venture with foreign companies will improve the pharmaceutical industry.

Conclusion: To Sum up, for improving the pharmaceutical industry in the quickest time possible, improvement of technological capabilities and investment in R&D should be considered.

Biography:

Shanker has  completed M.Pharmacy from JNT University Hyderabad at the age of 25, at present pursuing 3^rd year of full time PhD in JNT University Hyderabad, India. He has published more than 15 research papers in international peer reviewed reputed journals.

Abstract:

In recent times, nanomaterials being used in antidiabetic studies for their exclusive properties such as small size, more surface area, biocompatibility and enhanced solubility. In view of this, present study aimed to evaluate the antihyperglycemic potential of biologically synthesized silver nanoparticles (BSSNPs) and Gymnema sylvestre (GS) extract. The crystalline nature of the BSSNPs was confirmed by x-ray diffraction; the characteristic peaks observed at 2θ = 38.23º, 44.33º, 64.56º and 77.45º were corresponded to (111), (200), (220) and (311). The SEM and HRTEM analysis divulges that the BSSNPs were spherical in shape. EDAX spectrum exhibit peaks for the presence of silver, carbon and oxygen atoms in the range of 1.0-3.1 keV. The results showed increased blood glucose, cholesterol, triglycerides, LDL, VLDL, huge loss in body weight, downturn in plasma insulin. The GS extract (200 mg/kg, 400mg/kg), BSSNPs (200 mg/kg, 400 mg/kg) and metformin 50 mg/kg were administered to the diabetic rats. BSSNPs at dose level of 400 mg/kg showed significant inhibition of blood glucose levels and lipid profile as compared with GS extract treated group. These detections revealed that BSSNPs possess potent antihyperglycemic and anti-hyperlipidemic activity and thus preferable over crude extract.

Biography:

After obtaining his master degree in Pharmaceutical technology and Cosmetology at Claude Bernard Lyon 1 University, France. Mourad SALA has started a PhD course in Pharmaceutical Technology since 2014 in the Claude Bernard Lyon 1 University, France. Meanwhile, he is a pharmacy student enrolled in 4-year hospital pharmacy residency programme in a teaching hospital (Hospice Civils de Lyon) in Lyon. He has already published two papers in reputed international journals. 

Abstract:

The DSD is an innovative preparation method of lipid nanocarriers. Both liposomes and solid lipid nanoparticles could be produced by varying the operational conditions. However, phospholipids are the only lipid materials used. Cyclosporine, a cyclic polypeptide and immunosuppressive agent, has been encapsulated by DSD.

The first solvent displacement consists in making phospholipids nanoprecipitate in a free-water media. Supramicelles are self-organised. During the second solvent displacement, an aqueous media is added to trigger the formation of liposomes or SLNs. The Cyclosporine is incorporated during the first step with phospholipids in ethanol. Ethanol concentration is the limiting factor orienting toward liposomes or SLNs. Those two nanostructures have been characterized.

By using the DSD method with a phospholipid concentration of 8,5mg/ml, liposomes were formulated with ethanol concentration of 16.6%. SLNs were obtained with up to 10% of ethanol. Both populations are nanosized and homogeneous. Respectively, the liposomes size was 107nm, with a PI (polydispersity index) equal to 0.24 and the SLNs size was 96 nm with a PI of 0.25. The encapsulation efficiency was between 65%-75%. This new method is based on two steps where phospholipids undergo organisational modifications. The first one passing by an intermediate state, a self-assembly into supramicelles is the critical stage.

The DSD is an original and innovative preparation method in which the nanoprecipitation conditions are of paramount importance. To date, none research work mentions such a technique allowing to encapsulate a polypeptide whether into liposomes or SLNs only on varying operational conditions.

Biography:

Khalid Al Kubaisi is a post-gradute researcher in his final year of PhD program in Public Health from Gloucestershire University, UK. He awarded  his master degree, Excellent with First Honours, in Public Health (MPH) from Hamadan bin Mohamed Smart University, Dubai during  the academic year 2010- 2012.  He attended his under graduate school at the University of Baghdad where he received his Bachelor degree in Science of Pharmacy in 1996. He spent ten years working as a pharmacist in UAE. His research’s interest is in self-medication practice and in the use of non-prescription drugs by university’s students. For example, investigating students’’ behavior towards reading the drug information leaflets. Recently, he developed and evaluated an Educational Intervention designed for modifying university students’ practice, knowledge, awareness and attitude in favor of responsible self-medication. 

Abstract:

There is a high prevalence of Self-medication practices among university students in United Arab Emirates (UAE). Although Over the Counter (OTC) drugs does not need prescription but they are safe only when used with proper guidance and with pharmacist consultation. Improper use of Oral Non-Prescription Drugs (ONPD) leads to carelessness and which may further leads to serious consequences. The aim of this research is to identify the common practices among university students using ONPD and its consequences.

A cross-sectional survey-based study was conducted from January to April 2014, among 2875 students in three randomly selected UAE universities. A structured and validated questionnaire was used to collect the responses of the students. SPSS version 20 was used to analyze the data.

A majority of the participants were females (76.3%). The most common cause of using ONPD was found to be minor illness (78.7%). Analgesics/Antipyretics were the common category of ONPD among the students. (84.9%). More than one-third of participants (34.1%; 461 of 1348) had used more than one drug for treating a single symptom (polypharmacy). The major risk associated with the ONPD users were found to be  belief of effectiveness of ONPD(OR = 0.348, 95% CI: .161-0.916, p<0.04); frequency of use behavior (OR = 2.368, 95% CI: 1.615-3.472, p<0.001); dose-seeking behavior (OR = 2.368, 95% CI: 1.615-3.472, p<0.00),  informal source of ONPD information(OR = 1.528, 95% CI: 1.096-2.130, p<0.02) and self-care orientation(OR = 2.331, 95% CI: 1.602-3.392, p<0.001).

The irresponsible behaviour of self-medication is high among university students in UAE. There is a need for an educational intervention to motivate students to be use non-prescription drugs more wisely.

Biography:

Paul Jazon I Sarne, the primary author of the study, graduated BS industrial Pharmacy from the University of the Philippines, Manila. He is currently working in United Laboratories Inc. as a researcher of natural products. This study is in cooperation with his groupmates as a requirement in their class on Alkaloids and Peptides under the program MS Pharmacy- Pharmaceutical Chemistry track: Dhennis T. Verzosa, Jhulez Anthony B. Dayrit, and Thea Frances Ruth N. Gonzales. The advisers of the study: Raymund B. Yu, MS & Levi-letlet Larcia, MS specialize in pharmaceutical chemistry and biochemistry; while Ronald R. Matias, PhD, Director of the Biological Sciences Department of United Laboratories, Inc., specializes in cell and molecular biology.

Abstract:

Alkaloidal extracts from Nephelium lappaceum L. (Rambutan) were investigated for selective anti-Staphylococcal and anti-MRSA activities. Ethanolic extracts of the pericarp, seeds and leaves were extracted for alkaloids (through a modified Stas-Otto Method I) and had undergone bioassay-guided fractionation via C18 SPE. Resazurin assays were done to determine MIC on clinically isolated Staphylococcus aureus and an MRSA variant. It was also used to determine safety on MDCK cell line (a non-cancerous mammalian cell line). Selectivity Index (SI), a ratio of the MDCK IC50 to MIC, was used as the measure of safety. The Ethanolic Pericarp Extract (EPE) was potently inhibitory to both S. aureus and MRSA, but was not selective (Sa & MRSA MIC=500 µg/mL, SI= 0.86). The alkaloid extract had similar MIC against MRSA but was more selective (Palk-B, SI> 2.00), while the third fraction of the alkaloidal extract had greatly improved antibacterial effect and selectivity (PB-f3, Sa & MRSA MIC=125 µg/mL, SI= 5.22). Results suggest the presence of a potent and selective anti-staphylococcal agent in PB-f3, which is also effective against MRSA.

Biography:

Samira Jafari received her master’s degree in analytical chemistry from the University of Tabriz and is currently pursuing her doctorate of chemistry in the analytical area at Imam Khomeini International University.  In addition to her master’s degree, Samira is well travelled in her schooling and as such has acquired a wide range of different chemistry styles.  With this experience, she gleaned and culminated a wide scope of techniques to develop a novel method for targeting various cancers efficiently with relatively low costs as compared to customized patient medicines.  With a generic customized cancer drug delivery system as described in her work, a new field of focus is presented that can make large strides in the fight against breast cancer.

Abstract:

Breast cancer is arguably the most common cancer faced by females today and the second most common cause of death in women in the world.  Indeed, this illness has garnered much attention in the field of pharmacology research.  Modern chemotherapeutic anticancer treatments have come a long way in the fight against breast cancer, thus bringing science closer to a cure.  However, the nature of these drugs is to attack both cancerous and non-cancerous cells at the same time.  With this current approach, a patient’s health, in addition to the cancer, can succumb to chemotherapies. To counter this problem, and increase the efficacy of cancer treatment, methods to customize therapeutic anti-cancer drugs have emerged in the form of targeted drug delivery systems.  In our studies, we present a method of a drug delivery using magnetic polyurethane.   Here, we describe a biocompatible magnetic polymer that can be used to direct chemotherapeutic drugs to cancerous regions in a body using an external magnet.  We show how a co precipitation method with magnetic nano-particles (MNPs) followed by a silica coating process and an in situ polymerization yields the magnetic polyurethanes used in this study. Verification of synthesis for the drug carrier is shown using the characterization techniques of scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), thermal gravimetric analysis (TGA), and a vibrating sample magnetometer (VSM).  The efficiency with drug loading and release of chemotherapeutic medications to the synthesized magnetic polyurethanes is monitored using an HPLC-UV detector.  Our findings present a new biocompatible drug delivery system with a high capacity for loading and directing tow various chemotherapeutic drugs simultaneously to cancer sites with little to no toxicity to the surrounding non-cancerous cells.