Day 2 :
Time : 10:00-10:40
A comprehensive review to be presented which shows the plant kingdom as an almost inexhaustible reservoir of potential drugs. The longstanding, successful use of herbal drug combinations in traditional medicine makes it necessary to find a rationale for the pharmacological and therapeutic superiority of many of them in comparison to isolated single constituents. As a result a new category, “Phytopharmaceutical” has emerged in several countries. There are many definitions but the core essence is “Phytopharmaceutical drug includes purified and standardised fraction with defined minimum four bio-active or phytochemical compounds (qualitatively and quantitatively assessed) of an extract of a medicinal plant or its part, for internal or external use of human beings or animals for diagnosis, treatment, mitigation or prevention of any disease or disorder but does not include administration by parental route” (CDSCO, Govt of India, 2016). In last decade we have seen the sluggish growth of Herbal/ Ayurvedic products and decrease in Pharma R&D output in terms of reduction in number of NCEs and increasing cost of new drug discovery. Current allopathic practice is unable to meet the unmet needs of multicomponent drug for multi target diseases. A number of problems, such as usefulness of RCTs in herbal medicine which are connected with the search for new prototype drugs of biological origin is also described. Special attention will be given on role of natural products in therapy; as biologically active compounds as such, as starting materials for (semi)synthetic drugs and, also as source of inspiration or as models for the synthesis of new drugs with better therapeutic, chemical or physical properties than the original compounds.
ITS College of Pharmacy, India
Time : 10:40-11:20
Presently, Dr. S. Sadish Kumar is the Director of I.T.S College of Pharmacy, Ghaziabad, India. He has been working as a Professor since 2010. He has over 2 decades of Research and Teaching experience.
He is a member of various professional bodies including Royal Society of Chemistry (RSC), UK. He has published 2 books, 30 research articles & presented research papers at conferences held in South Korea, USA, Germany & Egypt and guided over 30 MPharm research projects in Marine and other natural products, guiding PhD projects as well.
His biography has been cited in Marquis Who’s Who in Medicine & Healthcare. He has been selected and commemorated for International Einstein Award for Scientific achievement, International Health Professional of the year to mention a few. His research thirst on Marine algae is widely noted.
Algal resources have a tremendous potential to be explored for the benefits of the mankind. Gelidiella acerosa is a genus of Red algae (Family: Gelidiellaceae) with high economic value found in many parts of India. As Gelidiella acerosa is used in the production of high quality agar, reported to possess a variety of phytoconstituents including Flavonoids, Alkaloids, Tannins, Proteins, Sulfated polysaccharides, Sulfono glycolipid, Sesquiterpenes, Monoterpenes, Phenols and various pharmacological activities, prompted us to investigate on this red alga with its hexane, ethyl acetate and methanolic extracts.
Among the extracts, methanolic extract of Gelidiella acerosa exhibited the highest percentage of free radical scavenging activity (68.42%) by Invitro DPPH assay which was comparable to that of the standard Ascorbic acid (76.55%). Methanolic extract also possessed the highest anti-inflammatory potential followed by ethyl acetate and hexane extracts in the Carrageenan induced paw edema and Cotton pellet induced granuloma models and it was found to be significant at p<0.001. The percentage inhibition was found to be 64.60% when compared to the standard, Diclofenac sodium (70.45%) at 10mg/kg concentration.
The antioxidant and anti-inflammatory activity of methanolic extract could be attributed to the highest amount of Flavonoid and Phenolic content, which were estimated to be 48.5 mg/g Quercetin and 34.34 mg/g Gallic acid equivalent respectively. Further investigations should be carried out to discover other potential phytoconstituents and pharmacological activities of G. acerosa.