Scientific Program

Conference Series Ltd invites all the participants across the globe to attend 10th Asia-Pacific Pharma Congress Singapore.

Day 2 :

  • Track 8, 9 & 10: Pharmaceutical Chemistry, Pharmaceutical Analysis & Pharmaceutical Microbiology
    Track 11 & 12: Pharmaceutical Biotechnology & Biochemistry and Molecular Biology
Location: Singapore City, Singapore

Session Introduction

Kanagathara Nachiappan

Sri Lakshmi Narayana Institute of Medical sciences, India

Title: Targeted drug delivery system of 5 - Fluorouracil with recombinant epidermal growth factor for brain tumor
Speaker
Biography:

N Kanagathara has her expertise in evaluation and passion in improving the research in Tumor. Her open and contextual evaluation model based on responsive constructivists creates new pathways for improving in research. She also carries research in other topics like Study on cervical dysplasia and also the multi-drug resistant effect on Mycobacterium tuberculosis by PCR is the current research experience. Targeted Drug delivery using rhEGF for brain tumor through nasal route. Designed and formulated nanoemulsions by conjugating rhEGF with anticancer drug and targeted brain tumor. Recombinant therapeutic protein process development - optimization in batch fermentation in research lab, Continuous fermentation at industrial level for commercial, purification, characterization, scale up & production.

Abstract:

5 Fluorouracil is an anticancer drug which has it effects on colon cancer, brain tumor, breast cancer, head & neck cancer. The aim of the present study was to formulate, optimize, and characterize 5 fluorouracil nanoemulsions for targeting brain tumor. The components of the formulation were optimized. The solubility study for the oil in surfactant & co-surfactant mix ratio was optimized. The characterization studies such as physical appearance, Dispersibility study, Density, Viscosity, pH, Surface tension, Globule size & Poly dispersity index, In vitro drug release, Thermodynamic stability were performed for all the ten formulations. Zeta potential, Optical microscopic analysis and Transmission electron microscopic analysis were done for the selected formulation. Based on the results of characterization NE3 was selected for conjugation with EGF. Two different methods such as physical mixing, solvent evaporation technique was done for conjugation of Epidermal growth factor with drug and physical mixing technique was optimized as the best method for conjugating the formulation. 5 Flurouracil nanoemulsions for targeting brain tumor and the pseudo ternary phase diagram for the solubility studies and the components of different phases were optimized and characterized through this study. The targeting efficiancy of the drug was studied by molecular docking for conjugated drug formulation and the binding energy level of Drug Conjugated Formulation with Epidermal Growth Factor is high when compared with the plain drug.

Nidhi Mishra

Indian Institute of Information Technology, India

Title: Design, synthesis and evaluation of novel chalcones as antimalarial agents
Speaker
Biography:

Nidhi mishra has completed  her PhD from the department of chemistry from university of Delhi in march 2009, after then she joined Birla institute of technogy and sciences Pilani, India as an assistant professor.Thereafter she moved to lucknow because of personal reasons. The author is currently an Assistant professor at the Institute of Information Technology, Allahabad. She has published several papers, book chapters and book.

Abstract:

Among various antimalarial agents chloroquine and its derivatives remains the backbone of medical care against malaria. Due to resistant strains of malarial parasite against chloroquine enhances the urgency to explore a new and cost-effective medicament to cure for malaria. Chalcones are stable, low molecular weight compounds and easy to prepare in a cost-effective manner, thus attracts attention of different scientists for the synthesis of antimalarial chalcones to find out a novel and efficacious drug. In-silico strategies have been of incredible importance in target identification and in prediction of novel drugs by means of bioinformatics tools to analyze possible active sites, drug likeness, molecular docking and ADME/T.

The utilization of complementary experimental and informatics methods increases the rate of success in many stages of the drug discovery, by assessing the interactions between the ligands and the binding site of the protein according to their binding affinity and elucidation of their functions to the discovery and development of compounds with desired properties. As structures of more protein targets get to be accessible through crystallography, NMR and bioinformatics methods. Also to win the battle against life-threatening diseases like Malaria, a global push is essential. Intervention of computers at some conceivable steps is imperative to cut down the expense and time needed in the drug discovery process.

Here we discuss the in silico and synthetic approach towards development of antimalarial chalcones.

Speaker
Biography:

Bienvenido S Balotro, RPh, MBA, MS, is an Assistant Professor of the Department of Industrial Pharmacy, College of Pharmacy, University of the Philippines Manila where he has taught pharmaceutical dosage form and drug delivery systems, pharmaceutical product development, and pharmaceutical marketing. Paola Marie Sabban, RPh, MS, is a Regulatory Affairs Associate at Pfizer (Phils.) Inc. She finished her Master of Science degree (Industrial Pharmacy track) at the University of the Philippines Manila, College of Pharmacy.

Abstract:

Background: Verapamil hydrochloride is a commonly prescribed drug in the management of hypertension, angina, and cluster headache prophylaxis. Verapamil hydrochloride suffers from the disadvantage of low bioavailability because of extensive hepatic metabolism (only 10% to 20% becomes bioavailable) and short half-life (2 to 4 hours). As a result, it requires frequent dosing of the drug leading to the problem of noncompliance in patients and alternating over and under doses of the drug. A method of circumventing hepatic first pass effect is by making the drug particle microsized(<10µm) and lipophilic.

Objectives: The aim of this study was to characterize the optimized microparticles of Verapamil hydrochloride entrapped in Poly (lactide-co-glycolide) (PLGA) (Verapamil HCl-PLGA) prepared through solvent displacement method followed by lyophilization.

Significance: This study sought to contribute to the improvement of the dosage form of Verapamil HCl by the application of polymeric drug delivery system. Through polymeric drug formulation, the low bioavailability due to hepatic first-pass effect is addressed by the transport of hydrophobic polymeric microparticles (size of <10µm) to the lymphatic system instead of the hepatic portal transport, therefore, avoiding extensive hepatic metabolism.

Methodology: The Verapamil HCl-PLGA microparticles were prepared through solvent displacement method followed by lyophilization. The optimization parameters for the formulation include particle size, polydispersity index, zeta potential, and entrapment efficiency. The optimized final formulation was further characterized based on percent (%) particle recovery, redispersibility, percent (%) drug loading, drug release kinetics, and morphology.

Results:  Based on the analysis of the data from solvent displacement method, increasing The PLGA 75:25 concentration resulted to an increase in the particles size, polydispersity index and entrapment efficiency, and a decrease in zeta potential; while the increase in Poloxamer 188 concentration led to a decrease in zeta potential and an increase in the entrapment of the drug; lastly, the increase in the pH of the non-solvent phase resulted to an increase in particle size. The addition of sucrose, led to a unfavorable increase in the particle size and polydispersity index, and a decrease in zeta potential and entrapment efficiency after lyophilization. The final product of the process was a heterogenous sized (<10µm) irregularly shaped particles (fragment-like), with an acceptable particle recovery, redispersibility, and percentage (%) drug loading, but poor release kinetic property (non-linear and decreasing concentration over time).

Conclusion:  The Verapamil HCl-PLGA microparticles prepared through solvent displacement method followed by lyophilization were able to meet the conditions noted by Chu and Lui (2008) for lymphatic transport: entrapment in a lipophilic polymer in terms of particle size requirement (<10µm).

Speaker
Biography:

P Rajasulochana is working as an Associate professor at department of Genetic Engineering in Bharath University located at Chennai, India.

Abstract:

Marine environment is rich source of bio-diversity. Algae are available in macro and micro level. These algae are available in various types like green algae, brown algae and red algae. One of the green algae is spirulina, rich source of proteins. In brown algae, padina species are important for different antibacterial, antiviral and antifungal activity. Red algae, kappaphycus  alvarezii  have various applications like neutraceutical, pharmaceutical and bioactive related effects. This algae have a lot of bioactive compounds which shows different activites like antibacterial, antifungal and antiviral activity.    Samples were collected from rameshwaran region,tamilnadu ,india. during the month of june. The samples were air dried and sun shaded for seven days. Kappaphycus (red algae) seaweed species were tested for their antibacterial activities using disc diffusion method. The species have primary and secondary metabolites, both metabolites show antimicrobial activities against different pathogens. Many bromo-compounds are identified for antimicrobial activites. Pseudomaonas flouresences, staphylococcus aureus, vibriochloera and proteus mirabilis are collected from madras university, Chennai. We subjected  kappaphycus  alvaerezii sample to identify the antibacterial activity using disc diffusion method. This review states that the red algae species have antibacterial activity against different bacterial species.

B Saritha

Justice Basheer Ahmed Sayeed College for Women, India

Title: Studies on antioxidant activity, phenol and flavonoid content of Pisonia alba span.
Speaker
Biography:

B Saritha is working as an Assistant professor in the department of Plant Biology and Plant Biotechnology at Justice Basheer Ahmed Sayeed College for Women, Teynampet in Chennai, India.

Abstract:

Pisonia alba leaf were collected from five different diverse places of Tamilnadu to Analysis the Antioxidant activity, Total Phenol and Flavonoid content of leaf extraction from various solvents( Aqueous, Ethanol, Petroleum ether, Chloroform, and acetone). Butylated Hydroxy Toluene (BHT), Gallic acid (GA) and Quercetin (Q) were taken as standard in case of antioxidant activity, phenol and flavonoid content respectively. The leaf extracts were evaluated for antioxidant activities by DPPH (1,1–diphenyl-2-picryl- hydrazyl) radical scavenging assay. The Maximum antioxidant activity was found in ethanolic leaf extract (65.7%) from Thiruvannamalai as compare to other accessions. Total phenol and flavonoid contents were quantitatively estimated. Total phenolic content measured by Folin-Ciocalteau method varied from 9.64 to 29.72 mg/Gallic Acid Equivalents (GAE)/g and the total flavonoid contents as measured by aluminum chloride method varied from 6.32 to 12.36 mg /Quercetin Equivalents (QE)/g.The ethanolic leaf extract of pisonia alba was found maximum in total phenol and flavonoid contents were 12.6 mg/ GAE /g and 7.5 mg QE /g respectively.

Speaker
Biography:

Dr Allen Lai received his Ph.D. and MPA, from Lee Kuan Yew School of Public Policy, National University of Singapore, M.Sc. (Preventive Medicine) from National Taiwan University and M.D. from Chung Shan Medical Dental University, Taiwan. He was the principal consultant at IMS Health Asia, a leading global information and technology services company in the healthcare industry, and the director of Institute of Health Economics & Management and the academic director of MSc Management of Health Industries in ESSEC Business School. He was also the attending physician in National Taiwan University Hospital and Taipei City Hospital. He has authored more than 40 articles in peer-reviewed journals. He holds several high key profile roles as President of ISPOR, Singapore Regional Chapter and concurrently the Consultant in Urology, and Advisor for Ministry of Health and Social Welfare, Taiwan. 

Abstract:

TBA

Speaker
Biography:

Samira Jafari received her master’s degree in analytical chemistry from the University of Tabriz and is currently pursuing her doctorate of chemistry in the analytical area at Imam Khomeini International University.  In addition to her master’s degree, Samira is well travelled in her schooling and as such has acquired a wide range of different chemistry styles.  With this experience, she gleaned and culminated a wide scope of techniques to develop a novel method for targeting various cancers efficiently with relatively low costs as compared to customized patient medicines.  With a generic customized cancer drug delivery system as described in her work, a new field of focus is presented that can make large strides in the fight against breast cancer.

Abstract:

Breast cancer is arguably the most common cancer faced by females today and the second most common cause of death in women in the world.  Indeed, this illness has garnered much attention in the field of pharmacology research.  Modern chemotherapeutic anticancer treatments have come a long way in the fight against breast cancer, thus bringing science closer to a cure.  However, the nature of these drugs is to attack both cancerous and non-cancerous cells at the same time.  With this current approach, a patient’s health, in addition to the cancer, can succumb to chemotherapies. To counter this problem, and increase the efficacy of cancer treatment, methods to customize therapeutic anti-cancer drugs have emerged in the form of targeted drug delivery systems.  In our studies, we present a method of a drug delivery using magnetic polyurethane.   Here, we describe a biocompatible magnetic polymer that can be used to direct chemotherapeutic drugs to cancerous regions in a body using an external magnet.  We show how a co precipitation method with magnetic nano-particles (MNPs) followed by a silica coating process and an in situ polymerization yields the magnetic polyurethanes used in this study. Verification of synthesis for the drug carrier is shown using the characterization techniques of scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), thermal gravimetric analysis (TGA), and a vibrating sample magnetometer (VSM).  The efficiency with drug loading and release of chemotherapeutic medications to the synthesized magnetic polyurethanes is monitored using an HPLC-UV detector.  Our findings present a new biocompatible drug delivery system with a high capacity for loading and directing tow various chemotherapeutic drugs simultaneously to cancer sites with little to no toxicity to the surrounding non-cancerous cells. 

Speaker
Biography:

Ibrahim H Kankia is a PhD Research Student in Molecular and Genetic Medicine at University of Abertay Dundee, United Kingdom. He is from Nigeria, the most populated country in Africa; He has keen interest in research and teaching. He started his PhD in September 2014 and he is basically working on the novel activators and inhibitors of NRF2 to improve life.

Abstract:

Luteolin enhances the increased in normal breast cell growth through NRF2 activation, although the exact mechanism of this activation is still unclear. The HER1 is one of the members of EGFR family which regulate the normal cellular proliferation, differentiation and maintenance. These receptors dimerize upon ligand binding, leading to activation of their tyrosine kinase domain. This subsequently led to the phosphorylation of their tyrosine residues in the intracellular domain. Nuclear factor (NRF2) is a transcription factor that regulates the expression of a battery of many genes including cytoprotective and detoxifying genes. Abnormal expression of both HER1 and NRF2 are reported in tumour initiation and studies have implicated both NRF2 and HER family in numerous cancers. In this study, we demonstrated that luteolin activated the NRF2 activity, which led to maintenance of HER1 protein expression and increased in cell growth of MCF10 cells. Additional investigation revealed that luteolin could lead to transcriptional activation of HER1 promoter activity by activating the NRF2 activity in the HER1 promoter region. Furthermore, activation of NRF2 by luteolin led to increase in total glutathione and other enzymes such as HO-1 and pAKT in the cell line used. Taken together, these data suggest that luteolin may activate the cell proliferation of normal breast cells through NRF2-mediated activation of HER1 expression and could be a novel avenue that luteolin induced NRF2 activation, which lead to increase normal breast cell growth.

Abdeen Mustafa Omer

Occupational Health Administration, Sudan

Title: Medicine distribution and financing alternatives
Speaker
Biography:

Abdeen Mustafa Omer (BSc, MSc, PhD) is an associate researcher at Occupational Health Administration, Ministry of Health and Social Welfare, Khartoum, Sudan. He has been listed in the book WHO’S WHO in the World 2005, 2006, 2007 and 2010. He has published over 300 papers in peer-reviewed journals, 200 review articles, 7 books and 150 chapters in books.

Abstract:

The strategy of price liberalisation and privatisation had been implemented in Sudan over the last decade, and has had a positive result on government deficit. The investment law approved recently has good statements and rules on the above strategy in particular to pharmacy regulations. Under the pressure of the new privatisation policy, the government introduced radical changes in the pharmacy regulations. To improve the effectiveness of the public pharmacy, resources should be switched towards areas of need, reducing inequalities and promoting better health conditions. Medicines are financed either through cost sharing or full private. The role of the private services is significant. A review of reform of financing medicines in Sudan is given in this article. Also, it highlights the current drug supply system in the public sector, which is currently responsibility of the Central Medical Supplies Public Corporation (CMS). In Sudan, the researchers did not identify any rigorous evaluations or quantitative studies about the impact of drug regulations on the quality of medicines and how to protect public health against counterfeit or low quality medicines, although it is practically possible. However, the regulations must be continually evaluated to ensure the public health is protected against by marketing high quality medicines rather than commercial interests, and the drug companies are held accountable for their conducts.

Speaker
Biography:

Anil Dewani is working at department of Quality Assurance in Pataldhamal Wadhwani College of Pharmacy in Yavatmal, India.

Abstract:

A novel, simple and MS compatible high-performance liquid chromatography (HPLC) method is reported for the simultaneous estimation of Ilaprazole (ILA) and Glimepiride (GLM) in rat plasma. The bioanalytical procedure involves extraction of ILA, GLM and Internal Standard (IS) from rat plasma with a solid phase extraction (SPE) process. The chromatographic analysis was performed on Waters-600 system using a isocratic mobile phase comprising methanol:water (80:20 % v/v) with pH of water modified to 3 using formic acid at a flow rate of 1.0 mL/min and Kinetex C18 column maintained at 30 ± 1 °C. The signals were monitored using a PDA detector set at 225 nm. IS,  Ilaprazole and Glimepiride eluted at 2.04, 4.7 and 7.4 min respectively and the total run time was 10 min. Method validation was performed as per US Food and Drug Administration guidelines and the results met the acceptance criteria. The calibration curve was linear over a concentration range of 10–600 ng/mL (r2 = 0.999). The intra- and inter-day precisions for ILA and GLM were (%RSD values) in the range of 1.52–9.74 and 1.52–11.76%, respectively, in rat plasma. The method was successfully applied in pharmacokinetic studies followed by oral administration of GLM and ILA in rats.

Phuong Nguyen

Hochiminh University of Medicine and Pharmacy, Vietnam

Title: Identification of potential inhibitors for Ebola virus: an in silico approach
Speaker
Biography:

Phuong Thuy Viet Nguyen has completed her PhD in Medicinal Chemistry at the University of Wollongong, Australia in 2015. She is currently a lecturer in Faculty of Pharmacy, University of Medicine and Pharmacy at Hochiminh city, Vietnam. She is interested in computer-aided drug discovery and development. Her research focuses on antiviral drug discovery, using in silico approaches such as molecular docking, molecular dynamics simulations and binding free energy in developing the inhibitors for the viruses.

Abstract:

Ebola virus (EBOV) is a fatal virus that causes severe hemorrhagic fever in human and animals. However, there is currently no FDA-approved drug for treating Ebola virus infection. Identification of potential inhibitors for Ebola virus has gained much attention of medicinal chemists in the last few years. Although few lead compounds were identified, the drug discovery for Ebola virus is significantly more challenging. In this study, in silico approaches were applied to explore potential inhibitors for EBOV infection. Initally, four protein targets for EBOV were identified through their important roles in viral pathogenesis and disease, namely VP24 (PDB id: 4MOQ), VP30 (PDB id: 5DVW), VP35 (PDB id: 3FKE), và VP40 (PDB id: 1H2C), respectively. The ligands were taken from some drugs which are in clinical testings from other anti-viruses potential compounds. Through blind dockings and focused dockings, the potential inhibitors and binding sites were discovered for different protein targets of EBOV. The docking results of the trial drugs are consistent with the experiment data. In the group of other potential compounds, there were some ligands which had abilities to well-bind with Ebola proteins such as Silybin (-9.5 kJ.mol-1), Harringtonine (-8.0 kJ.mol-1), Homoharringtonine (-8.3 kJ.mol-1), Chat 5 (-8.2 kJ.mol-1). Among these ligands, after screening through Lipinski 5 rules, Silybin was the only suitable one which could be used as lead compounds for EBOV drug discovery. This study provided helpful information to considerably assist in drug discovery of antiviral agents for Ebola virus.

Speaker
Biography:

Faten Zahran Mohamed  has completed her PhD at the age of 30 years from Ein Shams University and postdoctoral studies from Ein Shams University School of Science. She is a professor in department of biochemistry, Faculty of Science in Zagazig University, Egypt. She has published more than 123 papers in reputed journals. 

Abstract:

This study was performed to investigate the antidiabetic effect of caffeic acid and 18β-glycyrrhetinic acid against diabetic rats. In this experiment, the animals were divided into five groups. Group I: Normal rats. Group II: Diabetic control rats. Group III: Diabetic rats treated with 18β-glycyrrhetinic. Group IV: Diabetic rats treated with caffeic acid. Group V: Diabetic rats treated with 18β-glycyrrhetinic and caffeic acid. Fasting blood glucose, insulin, glutathione reductase (GR), glutathione peroxidase (GPx), total antioxidant (TAO), catalase (CAT), and superoxide dismutase (SOD) and malondialdehyde (MDA) were analyzed. Results: Fasting blood glucose and MDA were significantly increased, whereas insulin, GR, GPx, TAO, CAT, and SOD were decreased significantly in diabetic rats. Though the diabetic rats treated with caffeic acid and 18β glycyrrhetinic acid individual exerts beneficial effects in all the biochemical parameters in diabetic rats. The combined treatment with caffeic acid and 18β-glycyrrhetinic acid normalized all the above-mentioned biochemical parameters in diabetic rats. Our findings demonstrated that 18β-glycyrrhetinic acid and caffeic acid either used individually or in combination to diabetic rats has antidiabetic effect and a good antioxidant property. From the results, the combined dose of 18β-glycyrrhetinic acid and caffeic acid to diabetic rats showed the promising effect and antioxidant property compared to individual treatments.

Md Shariful Islam

Mawlana Bhashani Science and Technology University, Bangladesh

Title: Leonurus sibiricus L. (honeyweed): A review of its phytochemistry and pharmacology
Speaker
Biography:

Md Shariful Islam is Faculty of Life Sciences and working in the Department of Biotechnology and Genetic Engineering, Mawlana Bhashani Science and Technology University, Bangladesh. Md. Shariful Islam has published many articles. His research interests are Biochemistry, Applied biochemistry, Physiology, Cellular Biochemistry, and Biotechnology. 

Abstract:

Leonurus sibiricus is a herbaceous plant found in many countries in Asia and America. This plant is widely practiced as a remedy for the treatment of diabetes, menstrual irregularities, and bronchitis. The approval of therapeutic implications of any drugs depends on the well characterized mode of actions of the compounds. The bioactive compounds like diterpenes, triterpenes, flavonoids and phenolic acids in Leonurus sibiricus show analgesic, antiinflammatory, anti-oxidant, anti-atherogenic and anti-hemorrhagic, anti-diabetic, antibacterial and allelopathic potency. Interestingly, the expression level of some genes is altered by the crude extract treatments, which are effective against cancers, diabetes and cardiovascular diseases where the molecular mechanisms are yet to be explored. Intriguingly, the extracts significantly induce nitric oxide production by endothelial nitric oxide synthase, a signaling molecule of vasodilation in combination with interferon-γ indicating positive effect on atherosclerosis. Further investigations are required to unlock the effects of bioactive compounds found in extracts at clinical settings.

Nashwa Masnoon

University of South Australia, Australia

Title: What is polypharmacy and how do we assess it?
Speaker
Biography:

Nashwa Masnoon is a PhD student at the University of South Australia (UniSA) and a pharmacist at the Royal Adelaide Hospital (RAH). She graduated from Bachelor of Pharmacy with Honours at UniSA in 2013. Her research experiences include developing a dose adjustment tool for warfarin, evaluating patient retention of information after warfarin counselling by clinical pharmacists and assessing the use of different psychotropic medications in a mental health hospital. As a result of having worked at the Repatriation General Hospital, Glenside Mental Health Hospital and the RAH, her areas of interest and publications are in geriatric medicine, psychotropic polypharmacy and the quality use of medicines. Nashwa’s PhD project focuses on optimising medication use in the older population. She is also involved in medication management for clients with disabilities. Nashwa received the Student Leadership Award in 2013 for mentoring students and continues teaching undergraduate students and interns in hospital pharmacy. 

Abstract:

Multimorbidity and the use of multiple medicines, commonly referred to as polypharmacy, is common in the older population. However there is no universal definition of polypharmacy. Three systematic reviews of polypharmacy definition, assessment tools and their associations with clinical outcomes were conducted using Medline/Embase databases of articles in English between 2000-2016 which i) defined polypharmacy ii) explored tools that assess polypharmacy and iii) examined clinical outcomes. A total of 112 articles were identified for polypharmacy definitions. While definitions ranged from two or more, to 11 or more medications daily, the most commonly reported definition was five or more medications daily (n=51, 45.5%). Few studies (6.3%) distinguished between appropriate and inappropriate polypharmacy but this distinction was not based on the pharmacology of medications. A total of 26 polypharmacy tools were identified and divided into two broad categories; tools with a scoring system (n=8) such as the Drug Burden Index and tools that do not provide a score (n=18) but criteria for appropriate or inappropriate prescribing such as the Beers Criteria. Out of the 26 tools identified, 50% were associated with at least one clinical outcome. Three of the tools were associated with mortality, hospitalisation and functional decline. Studies have used the number of medicines to define polypharmacy which may not be clinically relevant without considering the pharmacology of medications involved. There is a need for tools which consider polypharmacy at an individualised-patient level to provide tailored guidance around optimising appropriate therapy and deprescribing inappropriate therapy to improve health outcomes.   

Speaker
Biography:

Ch Supriya has her expertise in evaluation and passion in improving the health and wellbeing. Her open and contextual evaluation model based on improving the activity of crude drugs by increasing the bio availability creates new pathways for improving healthcare.

Abstract:

The flavonoids comprise a large class of low-molecular-weight plant metabolites ubiquitously distributed in food plants. These dietary antioxidants exert significant antitumor, antiallergic, and anti-inflammatory effects. Quercetin is a naturally occurring chemical found in fruits and vegetables. Flavonoids such as quercetins, are antioxidants, antibacterial and anti inflammatory agents. The molecular mechanisms of their biological effects remain to be clearly understood. Flavonoids have more therapeutic activity and less solubility. So, its activity can be enhanced through enzymatic conjugation or sulfation by Arylsulfotransferases or by other hydrophilic enzymes. In the present work, we have taken Papain conjugated Quercetin enzyme to increase its solubility and bioavailability. Enzyme conjugation was analysed by HPLC method. HPLC at 255nm using an isocratic mobile phase (60:40, acetonitrile: 0.1% acetic acid). HPLC was evaluated through high accuracy, precision, recovery and that enzymatic conjugation may enhance the antibacterial, analgesic activity and antifungal activity was found to be increased. 

Speaker
Biography:

Ebrahim Doostzadeh is a PhD student at Department of Technology Management, in Roudehen Branch, Islamic Azad University at Tehran, Iran.

Abstract:

Objectives: The pharmaceutical market is a complex market due to its complicated supply chain and the extent of government regulations in all aspects of the trade life cycle of drug development. Considering the importance of pharmaceuticals for society and the relevant trend of globalization, managing pharmaceutical industry effectively and efficiently is vital, particularly in developing countries. The present study determines factors affecting the development of the Iranian pharmaceutical industry, based on pharmaceutical mangers` point of view.

Methods: In this study we assessed Managers` perspective about the internal and external key factors affecting the development of pharmaceutical industry. Finally, their perspective about the solutions for development of pharmaceutical industry was assessed. Accordingly, a self-designed questionnaire was sent to 65 managers at Tamin Pharmaceutical Investment Company (TPICO)1, of which 51 questionnaires were answered by the managers.

Result: Most managers believed generic scheme reflect negatively on the development of the pharmaceutical industry, and that external factors have a great impact on its improvement.  They believe that branded- generic transition along with supporting regulations, investment in Research and Development (R&D), and joint venture with foreign companies will improve the pharmaceutical industry.

Conclusion: To Sum up, for improving the pharmaceutical industry in the quickest time possible, improvement of technological capabilities and investment in R&D should be considered.

Speaker
Biography:

Mary Suja R is director of William Research Centre at Nagercoil, India. 

Abstract:

Breast Cancer is the leading cause of death in women worldwide among other types of cancers. The present investigation was mainly focused on the scientific analysis to assess the qualitative and quantitative phytochemical constituents, antioxidant potential, cytotoxic, antiproliferative and apoptotic effect of Traditional Siddha Breast Cancer Medicine. To create an awareness regarding the value of Siddha Medicine and to utilize the cheapest source of Traditional Siddha Breast Cancer medicine to relapse the patient from breast cancer without side effects. The plant materials required for the formulation of medicines were collected from the hills and hill locks of Molliadi and other ingredients were procured from Siddha raw drug stores. The herbal formulations were prepared as prescribed in the Palm leaf parchments by my Grandpa and Ancestors, Traditional Siddha Practitioners, India.  The scientific analysis of Siddha Breast Cancer medicines and case reports highlight the effect of medicine to relapse the patient from breast cancer. This research work makes the society to believe that treatment is also possible without any significant side effects. Apparently, the promising active principles and underlying mechanism by which this activity was exhibited need to be further investigated.