Subhasis Chakrabarty
NSHM College of Pharmaceutical Technology, India
Title: Combination of surfactant and reverse iontophoresis to enhance transdermal extraction of Gabapentin
Biography
Biography: Subhasis Chakrabarty
Abstract
Recently, the research has been focused on noninvasive methods for frequent clinical and therapeutic drug monitoring which could avoid blood sampling and improve patient compliance. Transdermal reverse iontophoresis offers a noninvasive tool for clinical and therapeutic monitoring of drug and indigenous molecules. We investigated the effect of sodium lauryl sulphate in receiver fluid (0-4%w/v) on reverse iontophoretic extraction of gabapentin. These experiments were carried out in custom made diffusion cell for a period of 4 h using pig ear skin. The extracted drug was analyzed by HPLC method. With the use of different concentration of sodium lauryl sulphate (2, 3, 4%w/v) in receiver fluid significantly increased the transport of drug and enhancement was 2.33, 1.76, and 1.10 folds respectively in anode chamber compared to the without sodium lauryl sulphate. Similarly, use of different concentration of sodium lauryl sulphate (2, 3, 4%w/v) in receiver fluid significantly increased the transport of drug and enhancement was 2.26, 1.61, and 1.37 folds respectively in cathode chamber compared to the without sodium lauryl sulphate. The maximum cumulative extraction was obtained with the 2% w/v sodium lauryl sulphate in both anodal and cathodal chamber. Reverse iontophoresis in conjugation with permeation enhancer had a significant synergistic effect in terms of extraction of drug across skin.